钙卫蛋白和降钙素原在不同类型炎症性胸腔积液中的表达水平及临床价值  

The expression level and clinical value of procalcitonin and procalcitonin in different types of inflammatory pleural effusion

作　　者：褚爱娟 楼亚玲[1] 王世俊[1] 田军 

机构地区：[1]余姚市人民医院,浙江余姚315400 [2]余姚市第二人民医院,浙江余姚315400

出　　处：《中国卫生检验杂志》2017年第15期2223-2224,2227,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨钙卫蛋白、降钙素原(PCT)在不同类型炎症性胸腔积液中的水平变化,并分析临床价值。方法收集化脓性胸腔积液患者30例、急性炎症性胸腔积液患者35例及非特异性炎症胸腔积液患者40例。检测3组患者胸腔积液中钙卫蛋白、降钙素原水平,分析其在3组患者中的变化。结果化脓性组、急性炎症性组患者的胸腔积液钙卫蛋白、PCT的水平显著高于非特异性炎症组;化脓性组患者的胸腔积液钙卫蛋白、PCT的水平显著高于急性炎症性组,差异均有统计学意义(P<0.01)。ROC曲线分析,钙卫蛋白的最佳阈值为893.3 ng/ml,AUC为0.87,灵敏度为79.5%,特异度为91.4%;PCT的最佳阈值为0.68 ng/ml,AUC为0.80,灵敏度为73.7%,特异度为83.1%。结论胸腔积液中钙卫蛋白、PCT测定对不同类型炎症性胸腔积液的鉴别诊断有一定的参考价值。Objective To investigate the changes of calprotectin and procalcitonin（ PCT） in different types of inflammatory pleural effusion,and analyze the clinical value. Methods 30 cases of suppurative pleural effusion,35 cases of acute inflammatory pleural effusion and 40 cases of non-specific inflammatory pleural effusion were collected. The levels of calprotectin and procalcitonin in pleural effusion were measured,and the changes in the three groups of patients were analyzed. Results The levels of calprotectin and PCT in pleural effusion in patients with suppurative group and acute inflammation group were significantly higher than those in non-specificity inflammation group; the levels of calprotectin and PCT in pleural effusion in patients with suppurative group were significantly higher than those in acute inflammation group,and the difference were statistically significant（ P〈0. 01）. ROC curve analysis showed that the optimal threshold of calprotectin was 893. 3 ng/ml,AUC was 0. 87,the sensitivity was 79. 5%,and the specificity was 91. 4%; the optimal threshold of PCT was 0. 68 ng/ml,AUC was 0. 80,the sensitivity was 73. 7%,and the specificity was 83. 1%. Conclusion The determination of calprotectin and PCT in pleural effusion has a certain reference value for differential diagnosis of different types of inflammatory pleural effusion.

关 键 词：不同类型 炎症性 胸腔积液 钙卫蛋白 降钙素原 

分 类 号：R730.4[医药卫生—肿瘤]