新型N-取代苯甲酰基-N′-(4-甲基苯并噻唑-2-基)硫脲衍生物的合成、晶体结构及抑菌活性  

Synthesis,crystal structure and antibacterial activity of new N-(substituted benzoyl)-N′-(4-methyl benzothiazole-2-base)thiourea derivatives

作　　者：曾振芳[1,2] 黄秋萍[1,2] 韦友欢[1,2] 黄秋婵[1,2] 郑广进[1,2] ZENG Zhen-fang HUANG Qiu-ping WEI You-huan HUANG Qiu-chan ZHENG Guang-jin(Department of Chemistry and Biological Science,Guangxi Normal University for Nationalities,Chongzuo 532200,China Guangxi Colleges and Universities Key Laboratory Breeding Base of Chemistry of Guangxi Southwest Plant Resources, Chongzuo 532200,China)

机构地区：[1]广西民族师范学院化学与生物工程系,广西崇左532200 [2]广西民族师范学院广西高校桂西南特色植物资源化学重点实验室培育基地,广西崇左532200

出　　处：《分子科学学报》2017年第4期337-341,共5页Journal of Molecular Science

基　　金：广西教育厅高校科研资助项目(YB2014416;2013YB271)

摘　　要：以取代苯甲酸和2-氨基-4-甲基苯并噻唑为原料合成5个新型N-取代苯甲酰基-N′-(4-甲基苯并噻唑-2-基)硫脲衍生物,化合物结构经元素分析、IR、1 H NMR和13 C NMR表征,X-射线单晶衍射测定了N-(4-甲氧苯甲酰基)-N′-(4-甲基苯并噻唑-2-基)硫脲(化合物1)的晶体结构,该晶体为单斜晶系,P21/c空间群,选择广西主要经济作物中常见的病原菌,对目标化合物进行室内抑菌活性测试,实验结果发现该类化合物具有一定的抑菌活性.5 new compounds N-（substituted benzoyl）-N′-（4-methyl benzothiazole-2-base）thiourea were synthesized from substituted benzoic acid and 4-methyl-2-benzothiazolamine.Their structures had been confirmed by elemental analysis,IR,~1H NMR and ^（13）C NMR.The crystal structure of the compound 1 was determined by X-ray diffraction analysis.Its crystal belongs to the triclinic system,space group P21/c.We choose common pathogenic bacterias on the main economic crops in guangxi province to proceed antibacterial activity test.The result showed that the compounds exhibited certainly antibacterial activity.

关 键 词：硫脲 合成 晶体结构 抑菌活性 

分 类 号：O626[理学—有机化学]