非酒精性脂肪性肝病发生和进展的综合影响因素  

Influence Factors on the Occurrence and Progression of Nonalcoholic Fatty Liver Disease

作　　者：李春苗[1] 罗雁[1] 张砚[1] 庄丽维[1] 

机构地区：[1]天津市海河医院消化内科,天津300350

出　　处：《医学综述》2017年第17期3401-3405,共5页Medical Recapitulate

摘　　要：非酒精性脂肪性肝病(NAFLD)是一种与遗传、环境、代谢应激等相关的慢性疾病,由于当今社会人群中肥胖的患病率迅速上升,NAFLD比酒精性肝病越来越普遍,NAFLD在疾病进展过程中可能发展为肝硬化、肝衰竭,最终发展为复杂的肝细胞癌。因此,在疾病的早期阶段对NAFLD的预防十分重要。在影响非酒精性脂肪性肝发病机制的因素中,"二次打击学说"、肌球蛋白轻链激酶(MLCK)与非酒精性脂肪性肝病三者之间存在密切联系,应用MLCK抑制剂ML-7对肠道屏障有保护作用,这些因素使MLCK在非酒精性脂肪性肝病发病机制中具有重要作用。Nonalcoholic fatty liver disease（NAFLD） is a kind of chronic disease related to genetic, environmental and metabolic stress, due to the rapidly increasing prevalence of obesity in today＇s society, NAFLD is becoming more common than alcoholic liver disease, and NAFLD may develop into liver cirrhosis,liver failure, and eventually complex hepatocellular carcinoma（HCC）. Therefore, prevention of NAFLD in the early stage is very important. Among the influence factors on the pathogenesis of NAFLDthe theory of ＂ second strike＂, myosin light chain kinase （MLCK） are closely associated with NAFLD. The application of MLCK inhibitor-ML has a protective effect on intestinal barrier. These factors make MLCK play an important role in the pathogenesis of NAFLD.

关 键 词：非酒精性脂肪性肝病 流行病学 二次打击学说 肌球蛋白轻链激酶 

分 类 号：R575.5[医药卫生—消化系统]