GnRH拮抗剂对子宫内膜异位症模型大鼠的实验研究  

Research on the effect of gonadotropin-releasing hormone antagonist in endometriosis rat models

作　　者：魏来 朱国智 夏志军[2] 

机构地区：[1]辽宁省昌图县中心医院妇产科,辽宁铁岭112599 [2]中国医科大学附属盛京医院妇产科,沈阳110004

出　　处：《实用药物与临床》2017年第8期876-878,共3页Practical Pharmacy and Clinical Remedies

基　　金：国家科技部十二五"重大新药创制"科技重大专项课题(2012ZX09401004);中华预防医学会科研资金支持项目(20130606)

摘　　要：目的观察促性腺激素释放激素(GnRH)拮抗剂阿巴瑞克(Abarelix)对大鼠移植性异位子宫内膜的抑制作用及其对子宫内膜异位症模型大鼠血清CA125、E_2、FSH、LH水平的影响。方法用外科自体移植术建立大鼠子宫内膜异位症动物模型,分为4组:对照组、去势组、GnRH激动剂丙氨瑞林组和阿巴瑞克组。分别测定给药前及给药4周后,各组模型大鼠异位子宫内膜体积及血清CA125、E_2、FSH、LH水平,观察给药前后各组模型大鼠异位子宫内膜体积及血清CA125、E_2、FSH、LH水平变化。结果给药4周后,阿巴瑞克组模型大鼠异位子宫内膜体积明显缩小,血清CA125、E_2、FSH、LH水平明显降低。结论阿巴瑞克对异位子宫内膜有抑制作用,对子宫内膜异位症有治疗作用,具有良好的临床应用前景。Objective To observe the inhibitive effect of GnRH antagonist on ectopic endometrium,and the effects of GnRH antagonist on serum CA125,E2,FSH and LH levels in endometriosis rat models.Methods The endometriosis model was established in rats and the model rats were divided into 4 groups：control group,non-ovary group,alarelin group and abarelix group,20 rats in each group.Changes in the volume of ectopic endometrium and the levels of serum CA125,E2,FSH and LH in endometriosis rat models before and after treatment were observed.Results After 4 weeks,the volume of ectopic endometrium and the serum levels of CA125,E2,FSH and LH reduced significantly in abarelix group.Conclusion Abarelix has inhibitive effect on ectopic endometrium,which can be used for the treatment of endometriosis.It is worthy of using clinically.

关 键 词：GNRH拮抗剂 子宫内膜异位症 大鼠模型 CA125 E2 FSH LH 

分 类 号：R-332[医药卫生] R711.71