Vav基因家族的分子调控机制及其与消化系恶性肿瘤的关系  

Relationship between Vav family members and digestive system malignancies

作　　者：李勇[1] 檀碧波[1] 

机构地区：[1]河北医科大学第四医院外三科,河北省石家庄市050011

出　　处：《世界华人消化杂志》2017年第23期2102-2108,共7页World Chinese Journal of Digestology

基　　金：河北省自然科学基金资助面上项目;No.H2016206173;河北省科技支撑基金资助项目;No.14277779D;河北省卫生和计划生育委员会医学重点研究课题;Nos.20150340;20160176~~

摘　　要：Vav基因家族包括Vav1、Vav2、Vav3基因,在生理及病理过程中都发挥着重要的调控作用.近年来发现Vav基因家族成员与消化系恶性肿瘤有较为密切的关系,已取得了一些研究成果.但迄今为止有关Vav基因家族成员与消化系恶性肿瘤关系的研究还不全面,且有一些结果不一致.因此,总结Vav基因家族成员的调控机制并分析其在消化系恶性肿瘤中发挥的作用有可能对阐明发病机制、提出新的治疗靶点有益.故本文对Vav基因家族的分子功能、调控机制及在消化系恶性肿瘤中的作用进行了综述及总结,并对该基因家族的潜在价值进行了预测.Vav1, Vav2, and Vav3 genes are three members of the Vav family, which play important roles in physiological and pathological processes. In recent years, it has been reported that Vav family members are closely associated with malignant digestive system tumors. However, there are still some inconsistent results. Thus, it is valuable to investigate the molecular mechanisms of Vav family members in malignant digestive system tumors, which may be beneficial in understanding the pathogenesis of these malignancies and identifying new therapeutic targets. In this paper, we review the functions, regulatory mechanisms, and roles of Vav family members in digestive system malignancies, and discuss their potential application value.

关 键 词：Vav基因家族 消化系恶性肿瘤 分子调控机制 应用 

分 类 号：R735[医药卫生—肿瘤]