肝纤维化逆转机制的研究进展及治疗概况  

Reverse mechanism and therapeutic overview of liver fibrosis

作　　者：吴兰婷[1] 刘文兰[2] 

机构地区：[1]首都医科大学基础医学院,北京市100069 [2]首都医科大学中医药学院,北京市100069

出　　处：《世界华人消化杂志》2017年第23期2123-2132,共10页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81573879;北京市自然科学基金资助项目;No.81273668;首都中医药研究专项重点课题基金资助项目;No.15ZY03~~

摘　　要：肝纤维化是肝脏对慢性损伤的一种修复反应,多是持续性肝脏损伤或纤维化刺激因子刺激产生的共有病理改变,是一项严重的全球性健康难题.近年来临床研究发现,由病毒性肝炎造成肝纤维化或肝硬化的患者,在成功接受病毒性肝炎治疗后,其肝纤维化甚至肝硬化发生了逆转现象.因此研究和了解肝纤维化逆转的机制有利于发现新的针对肝纤维化的治疗靶向.本文就近年来有关肝纤维化逆转机制的研究以及治疗概况作一综述。Liver fibrosis is a repair response to chronic liver injury. It is common pathological changes resulting from chronic liver damage or exposure to fibrosis stimulators. Liver fibrosis has become a serious global health problem now. According to recent clinical studies, liver fibrosis or even cirrhosis caused by viral hepatitis in some patients can be reversed after successful treatment. Therefore, studying and understanding the mechanism of liver fibrosis reversal can help to discover new targets of treatment for liver fibrosis. This review discusses the mechanism to reverse liver fibrosis according to studies in recent years and gives an overview of its treatment.

关 键 词：肝纤维化 逆转 肝星状细胞 治疗 

分 类 号：R575.2[医药卫生—消化系统]