320排CT双入口灌注参数与肺癌Ki-67表达率的相关性分析  

Correlative Study of 320 Detector CT Dual-Input Perfusion Imaging and Expression of Ki-67

作　　者：刘佩[1] 岳松伟[1] 高剑波[1] 刘洋[1] 宋雅信 刘甲[1] 赵曦曈 常丽阳 

机构地区：[1]郑州大学第一附属医院放射科,450052 [2]郑州大学第一附属医院心内科,450052

出　　处：《临床放射学杂志》2017年第8期1106-1109,共4页Journal of Clinical Radiology

摘　　要：目的应用320排CT双入口灌注成像技术,探讨灌注参数与肺癌Ki-67阳性表达率的关系。方法搜集临床经穿刺或术后病理证实的肺癌患者34例,采用东芝320排CT(Aquilion ONE,Toshiba Medical Systems,Otawara,Japan)扫描器对所有患者进行肺部动态容积灌注扫描,运用双入口灌注成像技术(DICTp)进行图像后处理分析得到肺动脉血流量(PF),支气管动脉血流量(BF)及灌注指数(PI);按Ki-67阳性表达率分为高表达(>50%)、中表达(26%~50%)、低表达(10%~25%)3组,分析各灌注参数与Ki-67阳性表达率的相关性。结果BF与Ki-67阳性表达率呈正相关(P<0.01,r=0.686),PI与Ki-67的阳性表达率呈负相关(P<0.05,r=-0.336),PF与Ki-67的阳性表达率无相关性(P>0.05)。结论 320排CT双入口灌注成像参数可评价肺癌Ki-67的阳性表达率,从而在术前为临床评估肺癌的生物学行为提供参考。Objective To study the correlation between 320 Detector CT dual-input perfusion imaging of lung cancer and expression of Ki-67. Methods Thirty-four patients who had lung cancer proved by pathology underwent the 320 Detector CT Dual-input perfusion examination. Using double-input mode to make post-processing analysis,the pulmonary flow（ PF）,bronchial flow（ BF）,and perfusion index[PI,PI = PF/（ PF ＋ BF） ]were thus obtained. According to the positive expression rate of Ki-67,we classified the patients into 3 groups： strongly positive（ 50%） 、moderately positive（ 26%-50%） 、weak positive（ 10%-25%）. The relationship between dual-input CT perfusion parameters of lung cancer and the expression of Ki-67 was analyzed. Results Ki-67 were positively correlated with CT perfusion parameters value of BF in lung cancer. There was no correlation with PF,and negative correlation with PI. Conclusion Dual-input CT perfusion imaging can evaluate the positive expression rate of Ki-67,and provide reference for the evaluation of the clinical biological behavior of lung cancer before operation.

关 键 词：双入口灌注 肺癌 KI-67 

分 类 号：R730.44[医药卫生—肿瘤] R734.2[医药卫生—临床医学]