中国南方前列腺癌患者p53基因codon 72多态性与局部进展前列腺癌根治术后综合治疗疗效的相关性研究  

Association between p53 codon 72 polymorphism and curative effect of postoperative therapy after radical prostatectomy in a southern Chinese population with locally advanced prostate cancer

作　　者：吴岩[1] 李琛[1] 于得水[1] 马贵[1] 徐新宇[1] 冯宁翰[1] 

机构地区：[1]江苏无锡市第二人民医院泌尿外科,江苏无锡214002

出　　处：《影像研究与医学应用》2017年第1期255-256,共2页Journal of Imaging Research and Medical Applications

摘　　要：目的:探讨p53基因codon 72多态性与中国南方局部进展型前列腺癌根治术后综合治疗疗效的相关性。方法:收集我院2008年5月至2014年3月期间收治的局部进展型前列腺癌患者47例,采集血液标本进行DNA提取及p53基因codon 72的基因型分析。结果:47例患者中基因型分布为CC型19.1%(9/47)、CG型38.3%(18/47)、GG型42.6%(20/47)。p53基因codon 72中,其基因分布存在诸多差异,认为与患者的多种因素(年龄、分期情况以及淋巴结是否发生转移)均无明显相关性(P>0.05)。全部患者的5年总生存率经统计为(86.7%)。比对codon 72不同基因型患者OS,组间数据结果经检验后未形成统计学意义。结论:中国南方前列腺癌患者p53基因codon 72多态性与局部进展前列腺癌根治术后的生存率无明显相关性。Objective： To investigate the association between p53 codon 72 polymorphism and curative effect of postoperative therapy after radical prostatectomy in a southern Chinese population with locally advanced prostate cancer. Methods： A total of 47 locally advanced prostate cancer patients treated with complex therapy after radical prostatectomy at Wuxi No.2 hospital were selected for this study. Blood DNA was extracted for p53 codon 72 polymorphism analysis using PCR- RFLEResults： Among the 47 patients, the genotype distribution was 19.1% （9/47） for CC, 38.3% （18/47） for CG and 42.6% for GG （20/47）. P53 gene codon72, the gene distribution there are many differences, that patients with a variety of factors （age, staging and lymph node metastasis occurred） were no significant correlation （P〉 0.05）. The 5-year overall survival of all patients was statistically （86.7%）. Compared with the different genotype of codon72 patients, the data between the two groups were not statistically significant. Conclusion： P53 codon 72 polymorphism might not be associated with curative effect of postoperative therapy after radical prostatectomy.

关 键 词：前列腺癌 P53基因 codon72 

分 类 号：R737.25[医药卫生—肿瘤]