双相情感障碍Ⅰ型患者灰质密度研究  

A comparative study on grey matter density in patients with bipolar disorder Ⅰ

作　　者：曹龙龙[1] 聂彬彬[2,3] 王静娟 薛志敏[5] 刘哲宁[5] 

机构地区：[1]天津市安定医院,天津市300222 [2]中国科学院高能物理研究所分析技术重点实验室 [3]北京市射线成像技术与装备工程技术研究中心 [4]首都医科大学宣武医院 [5]中南大学湘雅二医院精神卫生研究所

出　　处：《精神医学杂志》2017年第3期161-164,共4页Journal of Psychiatry

基　　金：国家自然科学基金项目(编号:81171287)

摘　　要：目的研究双相情感障碍Ⅰ型患者与健康人群比较,脑灰质密度具有差异性的脑区。方法选取年龄、性别、受教育年限匹配良好的双相情感障碍Ⅰ型患者(患者组)22例和健康对照(对照组)25名,试验样本均完成头部结构相的磁共振影像资料收集,使用SPM对结构影像资料进行预处理,分析两组灰质密度差异有统计学意义的脑区分布。结果与对照组比较,患者组灰质密度降低的脑区主要包括右侧颞上回,右侧颞下回(P<0.05);患者组灰质密度增大的脑区主要包括左侧颞下回、左侧颞中回以及左侧小脑脚1区部位(P<0.05)。结论与健康对照比较,双相情感障碍Ⅰ型患者灰质密度降低的脑区主要集中于右侧颞上回、颞下回,灰质密度增大的脑区主要集中于左侧颞下回、颞中回以及左侧小脑脚1区部位。Objective To explore the differences of grey matter density in patients with bipolar disorder I and healthy persons. Methods 22 patients with bipolar disorder I in patient group and 25 healthy controls who were age-,gender-and education level-matched with the patient group in control group were selected. Their brain structural magnetic resonance imaging（ MRI） data had been collected and preprocessed with SPM for analyzing the differences of grey matter density. Results Compared with control group,patient group exhibited decreased grey matter density mainly in right temporal superior gyrus and right temporal inferior gyrus（ P〈0. 05）,and exhibited increased grey matter density mainly in left temporal inferior gyrus,left temporal middle gyrus and left Cerebelum_ Crus1（ P〈0. 05）. Conclusion Compared with healthy controls,patients with bipolar disorder I exhibit decreased grey matter density dominantly in right temporal superior/inferior gyrus,while increased in left temporal inferior/middle gyrus and left Cerebelum_Crus1.

关 键 词：双相情感障碍 磁共振成像 基于体素的形态学分析 灰质密度 

分 类 号：R749.4[医药卫生—神经病学与精神病学]