精神分裂症阴性症状的药物治疗进展  

Review of pharmacotherapy advance in schizophrenic negative symptoms

作　　者：潘惠[1,2] 杜向东[2] 

机构地区：[1]常熟市第三人民医院,江苏常熟215500 [2]苏州大学附属广济医院,江苏苏州215000

出　　处：《四川精神卫生》2017年第4期384-388,共5页Sichuan Mental Health

摘　　要：阴性症状作为精神分裂症核心症状之一,目前仍缺乏有效的靶向性治疗,是影响预后的主要不利因素。根据不同的生物学机制,当前临床研究主要关注抗精神病药单用或其联合抗抑郁药、抗焦虑药、谷氨酸化合物及抗炎药等对阴性症状的疗效,本文通过对精神分裂症阴性症状常用的药物疗法进行归纳总结,分析不同疗法的效果,以期为临床治疗阴性症状提供参考。Negative symptom is one of the core symptoms of schizophrenia and is a main adverse factor which effects schizophrenic prognosis, as there is no effective treatment now. According to various biological mechanisms, clinical researches mainly focus on the effects of used antipsychotics alone as well as combined with antidepressants, anxiolytics, glutamate compounds and anti - inflammatory drugs on negative symptoms currently. This review summarized the common drug therapies for negative symptoms and analyzed the effects of different therapies, which may provide references for the clinical treatment of negative symptoms.

关 键 词：精神分裂症 阴性症状 药物治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]