根管封闭剂MTA、AH-Plus对大鼠皮下组织相容性的研究  

Biocompatibility evaluation of 2 root canal sealers MTA and AH-Plus in subcutaneous tissue of rats

作　　者：穆云静[1] 焦艳萍 屈铁军 王勇[4] 王娟[3] 刘宝刚[5] 余擎 

机构地区：[1]北京大学口腔医院第二门诊部,北京100081 [2]军委机关事务管理总局复兴路24号院门诊部,北京100842 [3]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔医学重点实验室,第四军医大学口腔医院牙体牙髓病科,陕西西安710032 [4]解放军第309医院旃坛寺门诊部,北京100034 [5]中国人民解放军火箭军总医院礼士路门诊部口腔科,北京100820

出　　处：《牙体牙髓牙周病学杂志》2017年第8期449-453,共5页Chinese Journal of Conservative Dentistry

摘　　要：目的:通过大鼠皮下埋植实验,比较MTA、AH-Plus两种根管封闭剂生物相容性的差异。方法:取SD大鼠28只,并将预制的MTA、AH-Plus两种根管封闭剂圆片和医用硅胶片(用于对照组)分别埋植于每只大鼠的背部皮下;分别于术后1、2、4、8周各随机处死7只大鼠,并采用HE染色法观察各埋植材料的组织相容性。结果:对照组和MTA组术后第1周时均表现为Ⅱ级炎症反应,其他各时间点均表现为I级炎症反应,两组各时间点相比P>0.05;AH-Plus组在术后第1、2、4周时均表现为Ⅱ级炎症反应,各时间点与对照组相比P<0.05,第8周时虽表现为I级炎症反应,但其炎细胞数仍明显高于对照组(P<0.05)。结论:MTA对大鼠皮下结缔组织的生物相容性优于AH-Plus。AIM To study the in vivo biocompatibility of root canal sealer MTA and AH - Plus. METH-ODS ：28 SD rats were randomly divided into 4 groups （n = 7 ） . The samples of MTA, AH-Plus and silica gel （ the con-trol） were respectively and subcutaneously implanted into 3 sites in each of the rats. 7 rats were respectively sacrificed 1,2,4 and 8 weeks after implantation, the histocompatibility of the materials was examined. RESULTS： Class Ⅱ in-flammatory reaction （IR） was observed in the control and MTA group at 1 week examination, class I IR was observed at 2, 4 and 8 week and no statistical significance was found between the 2 group （P 〉 0. 05 ） . 1, 2 and 4 weeks after op-eration ,AH-Plus group showed Class Ⅱ IR （vs control group, P 〈 0. 05 ） , at week 8, inflammatory response turned to Class I. CONCLUSION： MTA has better biocompatibility in rat subcutaneous connective tissue than AH-Plus.

关 键 词：根管封闭剂 生物相容性 MTA AH-plus 

分 类 号：R783.1[医药卫生—口腔医学]