奥沙利铂联合卡培他滨治疗老年胃肠恶性肿瘤的临床疗效  

Clinical effect of oxaliplatin combined with capecitabine in the treatment of elderly gastrointestinal malignancies

作　　者：尤玮[1] 

机构地区：[1]四川省自贡市第四人民医院肿瘤科,643000

出　　处：《临床合理用药杂志》2017年第24期30-31,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨奥沙利铂联合卡培他滨治疗老年胃肠恶性肿瘤的临床疗效。方法选取自贡市第四人民医院2014年2月—2016年8月收治的老年胃肠恶性肿瘤患者98例,按照随机数字法将患者分为对照组与观察组,各49例。对照组予以奥沙利铂+5-氟尿嘧啶化疗方案,观察组患者予以奥沙利铂+卡培他滨化疗方案,3周为1个疗程。比较两组患者临床疗效及毒副作用发生情况。结果观察组患者治疗总有效率为91.84%,高于对照组的73.47%(P<0.05)。两组患者毒副作用发生率比较,差异无统计学意义(P>0.05)。结论奥沙利铂联合卡培他滨治疗老年胃肠恶性肿瘤安全有效。Objective To evaluate the efficacy of oxaliplatin combined with capecitabine in the treatment of elderly gastrointestinal malignancies. Methods A total of 98 cases of elderly gastrointestinal malignancies patients were selected from February 2014 to August 2016 in Zigong Fourth People＇s Hospital,which were divided into control group and observation group according to random number table,49 cases in each group. Control group was given oxaliplatin ＋ 5-fluorouracil,observation group was given oxaliplatin ＋ capecitabine,three weeks as a course of treatment. The clinical effect and toxic and side effects were compared between the two groups. Results The total effective rate of observation group was 91. 84%,which was higher than control group（ 73. 47%）（ P〈0. 05）. No significant difference of the incidence rate of toxic and side effects was found between the two groups（ P〉0. 05）. Conclusion Oxaliplatin combined with capecitabine chemotherapy have a significant clinical effect in the treatment of elderly gastrointestinal malignancies,and with higher safety.

关 键 词：胃肠恶性肿瘤 奥沙利铂 卡培他滨 治疗结果 

分 类 号：R735[医药卫生—肿瘤]