术前诱导化疗联合术后放疗治疗口腔癌的疗效  

Efficacy of preoperative chemotherapy combined with postoperative radiotherapy in treating oral cancer

作　　者：沈想[1] 张潇雯[1] 朱江[1] SHEN Xiang ZHANG Xiaowen ZHU Jiang(Department of Stomatology , Affiliated Hospital, Nantong University, Nantong 226001, CHINA)

机构地区：[1]南通大学附属医院口腔科,江苏省226001

出　　处：《江苏医药》2017年第16期1165-1167,共3页Jiangsu Medical Journal

摘　　要：目的探讨术前诱导化疗联合术后放疗治疗Ⅲ、Ⅳ期口腔癌的疗效。方法 48例口腔癌患者随机均分为对照组(给予手术+单纯放疗方案)和治疗组(给予术前诱导化疗+手术+术后放疗方案),比较两组治疗后近期生存率、总有效率和不良反应发生情况。结果治疗组1年生存率(75.0%vs.58.3%)和2年生存率(66.7%vs.45.8%)均高于对照组(P<0.05)。治疗组治疗总有效率高于对照组(83.3%vs.54.2%)(P<0.05)。治疗组白细胞降低、呕吐恶心、放射性皮疹和口腔黏膜受损等不良反应发生率均高于对照组(P<0.05)。结论口腔癌患者联合实施术前诱导化疗和术后放疗能有效提高临床治疗效果,同时能够提高患者近期生存率。Objective To explore the clinical efficacy of preoperative chemotherapy combined with postoperative radiotherapy in treating the patients with oral cancer.Methods Forty-eight patients with stageⅢ and Ⅳ oral cancers were equally and randomly divided into groups of A（given surgery and radiotherapy）and B（given preoperative chemotherapy,surgery and postoperative radiotherapy）.The short-term survival rate,overall effectiveness rate and adverse effects were compared between two groups.Results The 1-year and 2-year survival rates in group A were higher than those in group B（75.0% vs.58.3% and 66.7% vs.45.8%）（P〈0.05）.The overall effectiveness rate in group A was higher than that in group B（83.3% vs.54.2%）（P〈0.05）.The incidences of leukocytopenia,vomiting and nausea,radioactive rash and oral mucosal damage were lower in group A than those in group B（P〈0.05）.Conclusion The preoperative chemotherapy combined with postoperative radiotherapy in treating the patients with oral cancer can effectively improve the overall effectiveness rate and short-term survival rate.

关 键 词：口腔癌 化疗 放疗 

分 类 号：R739[医药卫生—肿瘤]