白介素10联合尼莫地平治疗蛛网膜下腔出血伴脑血管痉挛的临床疗效观察  

Clinical effect observation of interleukin 10 combined with Nimodipine in treatment of subarachnoid hemorrhage complicated with cerebral vasospasm

作　　者：杨波[1] 刘曙艳[1] 

机构地区：[1]焦作市第二人民医院,河南焦作454000

出　　处：《中国民康医学》2017年第12期19-20,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:观察白介素10(IL-10)联合尼莫地平治疗蛛网膜下腔出血(SAH)伴脑血管痉挛(CVS)的临床效果。方法:将84例SAH患者分为对照组(n=42)和治疗组(n=42),对照组患者常规卧床,应用尼莫地平注射液、脱水及对症治疗;治疗组患者在对照组治疗的基础上加用IL-10治疗。结果:治疗组的总有效率为97.6%,明显高于对照组的85.7%,两种疗法的总有效率差异有统计学意义(P<0.05);治疗组患者脑血管痉挛的发生率,再出血的发生率、病死率均低于对照组,差异具有统计学意义(P<0.05)。结论:IL-10联合尼莫地平治疗蛛网膜下腔出血伴脑血管痉挛患者的临床疗效优于单纯尼莫地平治疗疗效。Objective To observe clinical effects of interleukin 10 （1L-10） combined with Nimodipine in treatment of sub-arachnoid hemorrhage （SAH） complicated with cerebral vasospasm （CVS）. Methods ： 84 patients with SAH were divided into control group （n = 42） and treatment group （ n = 42） . The control group adopted bed rest, conventional dehydration and Nimodipine treat-ment, while the treatment group was treated with 1L-10 based on those of the control group. Results ： The total effective rate of the treatment group （97.6% ） was significantly higher than that of the control group （85.7% ） , and the difference was statistically signifi-cant （P〈0. 05 ）. Moreover, the CVS incidence, rebleeding incidence, and mortality rate of the treatment group was lower than those of the control group, and the differences were statistically significant （P〈0.05）. Conclusions： 1L-10 combined with Nimodipine in the treatment of SAH complicated with CVS is superior to single Nimodipine.

关 键 词：白介素10 尼莫地平 蛛网膜下腔出血 脑血管痉挛 

分 类 号：R743.35[医药卫生—神经病学与精神病学]