PTEN基因与消化系统器官纤维化  

PTEN and Digestive Organ Fibrosis

作　　者：张晓云[1] 郝建宇[1] 

机构地区：[1]首都医科大学附属北京朝阳医院消化内科,北京100020

出　　处：《协和医学杂志》2017年第4期300-304,共5页Medical Journal of Peking Union Medical College Hospital

基　　金：国家自然科学基金面上项目(81470888)

摘　　要：PTEN基因是目前发现的重要抑癌基因之一,其蛋白产物具有独特的蛋白磷酸酶及脂质磷酸酶双重活性。PTEN蛋白分布广泛、生物学功能复杂、调节方式多样,可通过多种信号转导途径对细胞的形态、增殖、分化、黏附、迁移等发挥调节作用。随着对PTEN基因的深入研究,揭示该基因与多种消化器官纤维化过程密切相关,并可能成为逆转及治疗纤维化的潜在靶点。PTEN gene is one of the most important tumor suppressor g e n e ,which acts through a unique protein phosphatase and lipid phosphates activity. PTEN protein has a wide distribution,complex biological func-tion ,and a variety of regulation modes,which can regulate the cell morphology,proliferation,differentiation,ad -hesion and migration through a variety of signaling pathways. With the further study of PTEN,it is found that the gene is closely related to the digestive process of many kinds of digestive organs,and may be a potential target for the reversing and treatment of fibrosis.【

关 键 词：PTEN 消化系统疾病 纤维化 细胞外基质 

分 类 号：R57[医药卫生—消化系统] Q71[医药卫生—内科学]