MicroRNAs在炎症性肠病发病机制中的研究进展  

The research of microRNAs in the pathogenesis of inflammatory bowel disease

作　　者：吴智娇 汪芳裕[1] 

机构地区：[1]南京大学医学院附属金陵医院(南京军区南京总医院)消化内科,南京医学硕士研究生210002

出　　处：《医学研究生学报》2017年第9期993-997,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81270453)

摘　　要：炎症性肠病(IBD)的发病机制至今仍未完全清楚,而mircoRNAs(miRNAs)的出现对IBD的研究提供了一种新的思路。miRNAs参与了细胞的多种生理功能,包括细胞分化、增值、信号转导和细胞凋亡等,与多种疾病的发病相关。研究发现miRNAs与肠道免疫系统、肠道黏膜屏障及肠道微生态相关,可能参与了IBD的发病过程。因此,miRNAs与IBD的关系值得进一步研究。文章就miRNAs在IBD发病机制中的作用和miRNAs应用于IBD的诊断及治疗方面的研究进展进行综述。To date, the pathogenesis of inflammatory bowel disease （IBD） is not fully understood. The study of microRNAs （miRNAs） provides a new opportunity for IBD research. miRNAs play an important role in cellular functions including cell differentia-tion, proliferation, signal transduction and apoptosis. Some studies discover that miRNAs have a role in gut immunity, intestinal muco-sa and gut microbiota. It is likely that miRNAs play a role in the development of IBD. So it^s necessary to study further about the rela-tionship between miRNAs and IBD. This review describes the current research of miRNAs in the pathogenesis of IBD and their applica-tion in the diagnosis and therapy of IBD.

关 键 词：炎症性肠病 MICRORNA 发病机制 临床转化 

分 类 号：R574[医药卫生—消化系统]