血压变异性与急性脑梗死合并H型高血压患者脑梗死严重程度及颈动脉内膜中膜厚度的关系研究  

Relationship between Blood Pressure Variability and Severity of Cerebral Infarction,Carotid Intima-media Thickness of Acute Cerebral Infarction Patients Complicated with H-type Hypertension

作　　者：高峰利 韩涛 张维 王梦珠 杨琼 

机构地区：[1]陕西省咸阳市中心医院神经内科,712000 [2]陕西省咸阳市中心医院眼科,712000 [3]陕西省咸阳市中心医院ICU,712000

出　　处：《实用心脑肺血管病杂志》2017年第8期45-48,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨血压变异性与急性脑梗死合并H型高血压患者脑梗死严重程度及颈动脉内膜中膜厚度的关系。方法选取2016年1月—2017年1月咸阳市中心医院收治的急性脑梗死合并高血压患者95例,根据同型半胱氨酸(Hcy)水平将所有患者分为对照组(Hcy<10 mmol/L,n=44)与观察组(Hcy≥10 mmol/L,n=51)。比较两组患者24 h血压、24 h血压变异性、颈动脉内膜中膜厚度、美国国立卫生研究院卒中量表(NIHSS)评分,血压变异性与急性脑梗死合并H型高血压患者NIHSS评分及颈动脉内膜中膜厚度的相关性分析采用Pearson相关性分析。结果两组患者24 h收缩压、舒张压比较,差异无统计学意义(P>0.05);观察组患者24 h收缩压变异性、舒张压变异性大于对照组(P<0.05)。观察组患者颈动脉内膜中膜厚度为大于对照组(P<0.05)。观察组患者NIHSS评分高于对照组(P<0.05)。Pearson相关性分析结果显示,观察组患者24 h收缩压变异性与NIHSS评分、颈动脉内膜中膜厚度呈正相关(r值分别为0.254、0.256,P<0.05);观察组患者24 h舒张压变异性与NIHSS评分、颈动脉内膜中膜厚度无相关关系(r值分别为0.203、0.198,P>0.05)。结论 24 h收缩压变异性与急性脑梗死合并H型高血压患者脑梗死严重程度及颈动脉内膜中膜厚度有关。Objective To investigate the relationship between blood pressure variability and severity of cerebral infarction,carotid intima-media thickness of acute cerebral infarction patients complicated with H-type hypertension.Methods A total of 95 acute cerebral infarction patients complicated with hypertension were selected in the Central Hospital of Xianyang from January 2016 to January 2017,and they were divided into control group（ with serum homocysteine level than 10mmol/L,n = 51） and observation group（ with serum homocysteine level equal or over 10 mmol/L,n = 44） according to serum homocysteine level. Observation index including 24-hour blood pressure,24-hour blood pressure variability,carotid intima-media thickness NIHSS score were compared between the two groups,correlations of blood pressure variability with severity of cerebral infarction and carotid intima-media thickness of acute cerebral infarction patients complicated with H-type hypertension were analyzed by Pearson correlation analysis. Results No statistically significant differences of 24-hour systolic blood pressure or 24-hour diastolic blood pressure was found between the two group（ P〉0. 05）; 24-hour systolic blood pressure variability and 24-hour diastolic blood pressure variability of observation group were statistically significantly larger than those of control group（ P〈0. 05）. Carotid intima-media thickness of observation group was statistically significantly larger than that of control group（ P〈0. 05）. NIHSS score of observation group was statistically significantly higher than that of control group（ P〈0. 05）. Pearson correlation analysis results showed that,24-hour systolic blood pressure variability was positively correlated with NIHSS score（ r = 0. 254） and carotid intima-media thickness（ r = 0. 256） of acute cerebral infarction patients complicated with H-type hypertension,respectively（ P〈0. 05）,while 24-hour diastolic blood pressure variability was not significantly linearly correlated with NIH

关 键 词：脑梗死 高血压 血压变异性 颈动脉内膜中膜厚度 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]