精神分裂症患者外周血白细胞miR-198、miR-206的表达及意义  

Expression and significance of peripheral blood leucocyte miR-198 and miR-206 in schizophrenics

作　　者：曲洪芳 朱云程[2] 王芳[3] 周军 张尉 常宪鲁 李国海 

机构地区：[1]镇江市精神卫生中心,江苏镇江212021 [2]上海市长宁区精神卫生中心,上海200335 [3]上海市杨浦区精神卫生中心,上海200093

出　　处：《江苏大学学报（医学版）》2017年第5期420-422,427,共4页Journal of Jiangsu University：Medicine Edition

基　　金：镇江市社会发展项目(SH2012058)

摘　　要：目的:探讨精神分裂症患者与健康人群外周血白细胞中miR-198、miR-206相对表达水平的差异。方法:选择精神分裂症患者40例作为病例组,性别、年龄匹配的40例健康人群作为对照组。采用实时荧光定量PCR技术检测两组个体外周血白细胞miR-198及miR-206的相对表达水平,阳性与阴性症状(PANSS)量表进行症状学评估。结果:病例组外周血白细胞miR-198、miR-206的相对表达明显高于健康对照组(t=20.363,P<0.01;t=33.762,P<0.01)。miR-198与miR-206的相对表达与PANSS各分量表评分相关性均无统计学意义(均P>0.05)。结论:miR-198、miR-206在精神分裂症诊断与疾病易感基因研究中可能具有一定的价值。Objective To evaluate the differences of peripheral blood leucocyte MicroRNA-198 （miR- 198） and MicroRNA-206（miR-206） levels between schizophrenics and healthy control. Methods： A total of 40 cases of schizophrenics were chosen as case group and 40 healthy people matched with gender and age were selected as control group. The relative expression levels（ ACt） of peripheral blood leucocyte miR-198 and miR-206 were measured by real time PCR. Symtomatology of schizophrenics was evaluated by Positive And Negative Syndrome Scale（ PANSS）. Results： The ACt of miR-198 and miR-206 （t = 20. 363 ,P 〈0. 01;t = 33. 762,P 〈 0. 01） were higher in the schizophrenics, compared with the healthy control. There were no linear correlation between the relative expression of miR-198 or miR-206 and PANSS（P 〉0. 05） . Conclusion; The level of peripheral blood leucocyte miR-198 and miR-206 may be useful for diagnosis and prognosis in schizophrenics.

关 键 词：精神分裂症 miR-198 miR-206 

分 类 号：R749.3[医药卫生—神经病学与精神病学]