食管癌根治术后辅助放化疗不良反应与临床因素的关系  

Analysis of the Relationship between Adverse Reactions and Clinical Factors in Patients with Esophageal Cancer after Radical Resection

作　　者：王琳[1] 陈梅[1] 明智[1] 魏成明[1] 

机构地区：[1]四川省自贡市第一人民医院,643000

出　　处：《实用癌症杂志》2017年第9期1482-1485,共4页The Practical Journal of Cancer

摘　　要：目的探讨食管癌根治性切除术患者术后辅助放化疗不良反应发生情况及其与临床因素的关系。方法选择50例食管癌术后辅助放化疗患者作为研究对象,观察其放射性食道炎(RE)、放射性肺炎(RP)及骨髓抑制等不良反应发生情况,并针对≥2级不良反应进行Logistic法因素分析。结果 RE:1级11例(22%)、2级19例(38%);RP:1级4例(8%)、2级7例(14%);骨髓抑制:1级16例(32%)、2级7例(14%)、3级1例(2%)。单因素分析结果显示:胸腔胃长度大小与≥2级RE相关(P<0.05),性别和胸腔胃体积大小与≥2级RP相关(P<0.05),是否接受了≥2个周期化疗与≥2级骨髓抑制相关(P<0.05)。多因素分析结果显示:胸腔胃长度大小是≥2级RE独立影响因素(P<0.05),胸腔胃体积大小是≥2级RP独立影响因素(P<0.05)。结论胸腔胃长度越长、体积越大发生≥2级RE、RP的风险越高,应在保证靶区照射剂量的同时密切注意患者不良反应发生情况,提高患者生存质量。Objective To investigate the incidence of postoperative adjuvant radiotherapy and chemotherapy adverse reactions in patients with esophageal cancer and their relationship with clinical factors. Methods 50 cases of esophageal cancer patients treated with adjuvant chemotherapy patients was the research object,RE,RP and the incidence of bone marrow suppression were observed,and analysis of logistic factors for ≥ 2 grade adverse reaction. Results RE： 1 grade 11 cases（ 22%）,2grade 19 cases（ 38%）; RP： 1 grade 4 cases（ 8%）,2 grade 7 cases（ 14%）; Bone marrow suppression： 1 grade 16 cases（ 32%）,2 grade 7 cases（ 14%）,3 grade 1 cases（ 2%）. Single factor analysis showed that the size and length of gastric ≥ 2grade RE（ P〈0. 05）,gender and gastric volume of gastric ≥ 2 RP（ P〈0. 05）,received ≥ 2 cycles of chemotherapy with ≥ 2grade myelosuppression related（ P〈0. 05）. Multivariate analysis showed that,the stomach size ≥ 2 grade RE independent factors（ P〈0. 05）,gastric volume ≥ 2 grade RP independent factors（ P〈0. 05）. Conclusion The risk of intrathoracic stomach length is longer,the greater the volume occurred more than 2 RE,the higher the RP,ensure the target doses while paying close attention to the occurrence of adverse reactions in patients,improve the quality of life of patients.

关 键 词：食管癌 术后辅助放化疗 放射性食道炎 放射性肺炎 

分 类 号：R735.1[医药卫生—肿瘤]