Gli1蛋白及E-cadherin蛋白在宫颈癌中的表达及临床意义  

Expression and clinical significance of Gli1 protein and E-cadherin protein in cervical cancer

作　　者：王丽[1] 朱莉[1] 

机构地区：[1]哈尔滨医科大学附属第四医院妇科,黑龙江哈尔滨150000

出　　处：《现代肿瘤医学》2017年第19期3117-3119,共3页Journal of Modern Oncology

摘　　要：目的:探讨Gli1蛋白及E-cadherin蛋白在宫颈癌中的表达及临床意义。方法:应用免疫组化SP法检测50例宫颈癌组织、30例宫颈上皮内瘤变(CIN)组织、40例正常组织中Gli1蛋白及E-cadherin蛋白的表达。结果:Gli1蛋白在宫颈癌组织中明显高于正常宫颈组织(P<0.05),E-cadherin蛋白在宫颈癌组织中明显低于正常宫颈组织(P<0.05)。结论:Gli1蛋白的高表达及E-cadherin蛋白的低表达与宫颈癌的病理分级、临床分期、淋巴转移等密切相关,且两者在宫颈癌的表达呈负相关。Objective：To study the expression of Glil protein and E - cadherin protein in cervical cancer. Methotis ：The expression of E -cadherin protein and Glil protein were detected by immunohistochemistry SP method in 50 cases of cervical cancer, 30 cases of cervical intraepithelialneoplasia（CIN） and 40 cases of normal cervical specimens. Results：Glil protein in cervical cancer was significantly higher than the normal cervical specimens（P 〈 0.05 ）. E - cadherin protein in cervical cancer was significantly lower than the normal cervical specimens （ P 〈 0.05 ）. Conclu- sion ：The high expression of Glil protein and low expression of E -cadherin protein were closely related to the patho- logical grade, clinical stage and lymph node metastasis of cervical squamous cell carcinoma, and the expression of Glil protein was negatively correlated with the expression of E - cadherin protein.

关 键 词：宫颈癌 免疫组化 GLI1蛋白 E-CADHERIN蛋白 

分 类 号：R737.33[医药卫生—肿瘤]