^(18)F-FDGPET/CT在伴发肿瘤的皮肌炎患者中的临床应用价值  

Clinical analysis of ^(18)F-FDG PET/CT screening tumor in patients with dermatomyositis

作　　者：杨艳[1] 程佑[1] 王明华[2] 谢莉[3] 

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]贵州医科大学附属医院核医学科,贵州贵阳550004 [3]贵州医科大学附属肿瘤医院核医学科,贵州贵阳550004

出　　处：《现代肿瘤医学》2017年第20期3309-3312,共4页Journal of Modern Oncology

基　　金：贵州省教育厅科技基金项目(编号:070700918)

摘　　要：目的:探讨^(18)F-FDG PET/CT在伴发肿瘤的皮肌炎患者中的临床应用价值。方法:回顾性分析2012年12月至2017年1月在我院行PET/CT检查的45例皮肌炎患者临床资料,结合病理学和/或随访结果,探讨^(18)F-FDG PET/CT在伴发肿瘤的皮肌炎患者中的临床应用价值。结果:45例皮肌炎患者中恶性肿瘤发生率为33.33%(15/45),平均年龄为58.33岁,男∶女为2.1∶1。^(18)F-FDG PET/CT发现恶性肿瘤的灵敏度、误诊率、特异度、漏诊率、准确性、阳性预测值和阴性预测值分别是100%、13.33%、86.67%、0、91.11%、78.95%、100%。肌肉/皮肤^(18)F-FDG弥漫性代谢异常增高组恶性肿瘤发生率36.84%(7/19),肌肉/皮肤^(18)F-FDG局部异常代谢增高组恶性肿瘤发生率28.57%(2/7),肌肉/皮肤^(18)F-FDG代谢无异常组恶性肿瘤发生率31.58%(6/19)。三组之间恶性肿瘤发生率比较,差异无统计学意义(P>0.05)。皮肌炎伴间质性肺病组恶性肿瘤发生率为15%(3/20),无间质性肺病组恶性肿瘤发生率48%(12/25)。两组之间恶性肿瘤发生率比较,差异有统计学意义(P<0.05)。结论:皮肌炎是否伴有肌肉/皮肤代谢异常和恶性肿瘤发生率无关,对年龄较大且无间质性肺病的男性皮肌炎患者,^(18)F-FDG PET/CT对于肿瘤筛查具有重要临床意义。Objective：To investigate the application value of 18F - fluorodeoxyglucose （lSF -FDG） positron emis- sion tomography and computed tomography （PET/CT） screening tumor in patients with dermatomysitis （DM）. Meth- ods ： Retrospective analysis was made of clinical data by whole body PET/CT of 45 patients with DM from December of 2012 to January of 2017. To investigate the application value of is F - FDG PET/CT screening tumor in patients with DM combined with pathology and/or follow - up. Results：There were 15 patients （33.33 % ）with malignancy in the 45 patients with DM and the average age was 58.33 years old. The ratio male than female was 2.1 ： 1. The sensitivity de- gree,misdiagnosis rate, specific degree, missed diagnosis rate, accuracy rate, positive predictive value and negative predictive value of lS F -FDG PET/CT screening tumor were 100%, 13.33% ,86.67% ,0,91.11% ,78.95%, 100% respectively. There were 7 patients （36.84%） associated with malignancy in 19 patients whose muscles/skin was dif- fuse metabolic increased. There were 2 patients （28.57%） associated with malignancy in 7 patients whose muscles/ skin was focal metabolic increased. There were 6 patients （31.58%） associated with malignancy in 19 patients whose muscles/skin was normal metabolism. There were no statistical differences among them （ P 〉 O. 05 ）. There were 3 pa- tients （15.00%） associated with malignancy in 20 patients with interstitial lung disease （ILD） and 12 patients （48%） associated with malignancy in 25 patients without ILD by 18F - FDG PET/CT. There was statistical difference between them （ P 〈 O. 05 ）. Conclusion： There is no relationship between malignancy and muscle/skin metabolism in patients with DM. For the male with DM who is older and without ILD, lSF -FDG PET/CT has an important clinical significance in screening tumor.

关 键 词：皮肌炎 肿瘤筛查 18F-FDG 间质性肺病 

分 类 号：R730.44[医药卫生—肿瘤]