肿瘤微环境在乳腺癌发生发展及治疗中的作用  

The role of tumor microenvironment in the occurrence,development and treatment of breast cancer

作　　者：李伟[1] 李文杰[1] 刘春晓[1] 钱诚[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院乳腺外科,黑龙江哈尔滨150086

出　　处：《现代肿瘤医学》2017年第20期3349-3353,共5页Journal of Modern Oncology

基　　金：黑龙江省教育厅海外学人科研资助项目(编号:1253HQ002)

摘　　要：乳腺癌是女性最常见的恶性肿瘤,且发病群体日趋年轻化。随着对其研究的不断深入,人们发现它的侵袭转移过程并非乳腺肿瘤细胞单方面的作用,而是乳腺癌与其所处的肿瘤微环境(tumor microenvironment,TME)相互作用而引起的。故应从乳腺肿瘤微环境中整体研究其发生发展,乳腺癌的治疗也应置于肿瘤微环境中综合考虑,这对寻找新的抗癌作用靶点意义重大。本文就肿瘤微环境中几种主要细胞和因子与乳腺癌发生发展的关系展开论述,并对乳腺癌新的抗癌作用靶点进行探索。Breast cancer is the most common malignant tumor in women, and the incidence group is increasingly younger. With the deepening of its research, it has been found that the invasion and metastasis of breast cancer is not a single side effect of cancer cells, but it＇s caused by interaction between breast cancer and tumor mic nt （TME）. So we should wholely research occurrence and development of breast cancer from tumor microenvironment, and the treatment should also be consdered in the tumor microenvironment, and it＇s of great significance to find new anticancer targets. In this paper, we discuss the relationship between the main cells and factors in the TME and the oc- currence and development of breast cancer, and explore new anticancer target in breast cancer.

关 键 词：肿瘤微环境 乳腺癌 发生发展 治疗 

分 类 号：R737.9[医药卫生—肿瘤]