流产经历和子宫肌瘤家族史对子宫肌瘤患病风险的影响  

Influence of abortion and family heredity history on the risk of uterine leiomyomas

作　　者：龚茁[1] 张敏敏[1] 王志萍[1] 

机构地区：[1]山东大学公共卫生学院流行病与卫生统计学系,山东济南250012

出　　处：《山东大学学报（医学版）》2017年第9期100-104,共5页Journal of Shandong University:Health Sciences

摘　　要：目的探讨流产经历和子宫肌瘤家族史对子宫肌瘤患病风险的影响,为预防子宫肌瘤提出建议。方法采用病例-对照研究方法,使用结构式问卷调查的方式收集山东省城市和农村的10个县级单位20~65岁常住已婚已育女性的流产经历和子宫肌瘤家族史,同时收集其年龄、身高等信息。运用Logistic回归模型分析流产经历和子宫肌瘤家族史与子宫肌瘤的关系。应用交互作用的相对超额风险(RERI)、归因于交互作用的比例(AP)和协同指数(S)三个指标评价流产史和子宫肌瘤家族史的相加交互作用。结果多因素非条件Logistic回归模型结果显示,流产史(OR=1.39,95%CI:1.06~1.80)和子宫肌瘤家族史(OR=2.07,95%CI:1.36~3.15)均为子宫肌瘤的危险因素。流产史和子宫肌瘤家族史对子宫肌瘤患病风险存在相加交互作用(S=5.51,AP=0.59,RERI=2.14)。有子宫肌瘤家族史的研究对象,1次流产和2次以上流产经历其子宫肌瘤患病风险分别增加1.78倍和2.77倍,而无遗传背景的研究对象中,流产经历对子宫肌瘤发病影响较小。结论有子宫肌瘤遗传背景的敏感人群应注意计划怀孕,谨慎流产以降低患子宫肌瘤的风险。Objective To explore the influence of abortion and family heredity history on the risk of uterine leiomyomas,and to provide suggestions for preventing uterine leiomyomas.Methods A case-control study was undertook in this study.A structural questionnaire survey was used collecting the information of abortion experience,family history of uterine leiomyomas,age,height and other information among 20-65 years old married women from 10 urban and rural areas in Shandong province,China.The relations between both abortion experience,family history of uterine leiomyomas and uterine leiomyomas were analyzed by using Logistic regression model.Relative excess risk of interaction,attributable proportion of interaction and synergy index were used evaluating the interaction of abortion and family history of uterine leiomyomas.Results Results from multivariate unconditional Logistic regression model showed that abortion（OR=1.39,95%CI：1.06-1.80） and family heredity history of uterine leiomyomas（OR=2.07,95% CI：1.36-3.15） were risk factors of uterine leiomyomas.There was an addictive interaction of abortion and family heredity history on the risk of uterine leiomyomas（S=5.51,AP=0.59,RERI=2.14）.Patients who had family heredity history and who had one or two more abortion increased the risk of uterine leiomyomas by 1.78 times and 2.77 times respectively.Conclusion Women who have family heredity history of uterine leiomyomas should pay attention to the pregnant plan and prevent abortion in order to reduce the risk of uterine leiomyomas.

关 键 词：子宫肌瘤 流产经历 家族史 交互作用 病例-对照研究 LOGISTIC回归分析 

分 类 号：R181.23[医药卫生—流行病学]