MMP-7在胃癌中表达上调的临床病理意义及预后价值  

Clinicopathological and prognostic significance of upregulated MMP-7 in gastric cancer

作　　者：沈小钢[1] 郭志义[1] 赵高平[1] 王林[1] 

机构地区：[1]四川省医学科学院.四川省人民医院胃肠外科,四川成都610072

出　　处：《实用医院临床杂志》2017年第5期128-131,共4页Practical Journal of Clinical Medicine

摘　　要：目的探讨基质金属蛋白酶-7(MMP-7)的表达与胃癌临床病理特征的关系以及对胃癌患者预后判断的价值。方法采用实时荧光定量PCR技术检测112例胃癌患者的癌组织和癌旁正常组织中MMP-7的表达。比较不同MMP-7表达水平胃癌患者的临床病理学特征,以及患者的生存分析。结果 MMP-7在胃癌组织中相对于正常胃黏膜组织高表达(P=0.001)。胃癌患者MMP-7表达上调,有更高的病理学分期(P=0.037),更深的组织浸润深度(P=0.028),淋巴结转移(P=0.015)和脉管浸润(P=0.042),以及更差的总体生存率(P=0.008)和无病生存率(P=0.015)。结论 MMP-7在胃癌患者中高表达并预示着更差的术后生存率。Objective To evaluate the clinicopathological significance of MMP-7 expression and investigate its prognostic val- ue in gastric cancer. Methods MMP-7 mRNA expression in cancerous tissue and corresponding normal mucosa tissue from 112 gastric cancer patients were analyzed by quantitative real-time RT-PCR. The clinicopathological characteristics and survival rates were com- pared among patients with various expression levels. Results The expression of MMP-7 mRNA was found to be upregulated in cancer- ous tissue compared to normal mucosa tissue （ P = 0. 001 ）. The expression levels were associated with advanced TNM stage （ P = 0. 037 ）, enhanced penetration depth （ P = 0. 028） ,lymph node metastasis （ P = 0. 015 ） and vessel invasion （ P = 0. 042）. Patients with upregulated MMP-7 showed a worse overall survival （P = 0. 008） and disease free survival （P = 0. 015）. Conclusion The ex- pression of MMP-7 is upreguhaed in cancer and associated with a decreased survival rate in patients with gastric cancer.

关 键 词：基质金属蛋白酶-7 胃癌 转移 预后 

分 类 号：R735.2[医药卫生—肿瘤]