小檗碱及其衍生物的抗癌机制研究进展  

Research Progress on Anti-cancer Effects of Berberine Derivatives

作　　者：朱学君 王译伟 张孝琴 王钦 张春 郭建敏 

机构地区：[1]西南医科大学,四川泸州646000

出　　处：《广州化工》2017年第17期3-6,共4页GuangZhou Chemical Industry

基　　金：四川省科技支撑计划项目(2014SZ0071);四川省科技支撑计划项目(省-市-校联合LY-18)

摘　　要：小檗碱又称黄连素,是一种异喹啉类季铵生物碱,具有抗菌抗炎、止泻、抗高血压、降血脂等作用。近年来研究发现小檗碱还有抗肿瘤的作用,而且毒副作用小,使得小檗碱在抗肿瘤研究方面前景更加广阔。但是小檗碱在肠道吸收较差,药理作用也还需要经临床研究进一步证实。近年来也有很多研究者对小檗碱的不同位点进行了结构修饰,期望得到水溶性更好,抗肿瘤活性更高的衍生物。本文就小檗碱及其衍生物的抗肿瘤机制的研究进展进行综述。Berberine, known as berberinum, is quaternary ammonium type isoquinoline alkaloid. It has multiple pharmacological activities such as anti-bacterial, anti-inflammatory, antidiarrheal, antihypertensive and hypolipidemic. Recent study finds that berberine has anti-tumor effect with limited toxic side effects which makes berberine a promising candidate for anti-tumor drug discovery. However, the bioavailability of berberine is poor due to its bad solubility. Recently, a series of berberine derivatives is reported aiming to get better biological activity and higher bioavailability. The anti-tumor mechanism of berberine and the progress of the study of berberine derivatives were reviewed.

关 键 词：小檗碱 小檗碱衍生物 抗肿瘤机制 结构修饰 

分 类 号：R914.5[医药卫生—药物化学]