不同分子亚型的浸润性乳腺癌中nm23表达及与腋窝淋巴结转移的关系  

Expression of nm23 in different molecular subtypes of breast carcinoma and its correlation to metastasis in axillary lymph nodes

作　　者：沈媛[1] 高玉霞[1] 朱东喆[2] 

机构地区：[1]廊坊市人民医院病理科,河北廊坊065000 [2]首都儿科研究所附属儿童医院新生儿科,北京100020

出　　处：《诊断病理学杂志》2017年第8期591-593,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨不同分子亚型浸润性乳腺癌中nm23的表达及其与腋窝淋巴结转移的关系。方法采用免疫组化法检测275例浸润性乳腺癌中nm23的表达水平。结果 nm23在激素受体阳性组、HER2受体阳性组、三阴性乳腺癌组中的表达率分别为84.3%、67.6%和54.5%(P<0.05);nm23的阳性率在无腋窝淋巴结转移组中高于有腋窝淋巴结转移组(P<0.05)。结论在乳腺癌的分子亚型中检测nm23的表达水平可以作为乳腺癌发生、发展的评价指标,更有助于指导其临床治疗和判断预后。Objective To investigate the expression of nm23 in different molecular subtypes of breast carcinoma and its correlation to metastasis in axillary lymph nodes. Methods The expression of ER,PR,HER2 and nm23 was detected immunohistochemically in 275 tissue specimens of invasive breast carcinoma. Results Based on immunohistochemical staining,the rates of nm23 expression were 84. 3% in ER/PR（ ＋） group,67. 6% in HER2（ ＋） group,and 54. 5% in triple negative breast cancer group（ P 〈 0. 05）. We also demonstrated that the expression of nm23 in the group without metastasis of axillary lymph nodes was higher than that in the group with metastasis of axillary lymph nodes（ P 〈 0. 05）.Conclusion To study the expression of nm23 in different molecular subtypes of breast carcinoma may provide an evaluation index of the development and progression of breast cancer,and it also contributes to the clinical treatment and prognostic evaluation of breast cancer.

关 键 词：NM23 分子亚型 乳腺癌 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]