重复经颅磁刺激治疗首发精神分裂症患者的临床随机对照研究  

A randomized controlled trial of repetitive transcranial magnetic stimulation in the treatment of first-episode schizophrenia

作　　者：宋欢[1] 李闫[1] 栾晓英 田建华[1] 

机构地区：[1]石河子绿洲医院,新疆石河子832000

出　　处：《临床医药文献电子杂志》2017年第37期7140-7142,共3页Electronic Journal of Clinical Medical Literature

基　　金：基金项目:早期联用重复经颅磁刺激治疗对首发精神分裂症患者认知功能影响的临床研究(2015YL03)

摘　　要：目的首发精神分裂症患者经重复经颅磁刺激(r TMS)治疗后的疗效评价。方法收集石河子绿洲医院2015年2月~2017年5月共100例首发精神分裂患者,并根据随机原则分组。两组均给予奥氮平片10~20 mg/日,实验组(共48例)联合r TMS治疗20次;对照组(52例)进行20次的联合伪r TMS,即无效刺激治疗。疗效评价工具为PANSS量表和WCST程序。结果 1.经不同方式治疗后,两组PANSS总分、阳性症状评分、阴性症状评分及精神病理评分均有下降趋势。2.两组PANSS及阴性症状评分的减分率存在明显差异(联合组vs对照组:40.8%vs30.1%;39.8%vs18.5%,P<0.05)。3.两组治疗后WCST各项测试结果均明显不同于治疗前(P<0.05)。且联合组治疗后患者的改善状况优于对照组(P<0.05)。结论奥氮平片联合r TMS的治疗方式能有效改善首发精神分裂症患者的阴性症状与认知功能,为早期干预及治疗首发精神分裂症提供新的方法。Objective To evaluate the efficacy of repeated transcranial magnetic stimulation （rTMS） in the treatment of first-episode schizophrenia. Methods A total of 100 first-episode schizophrenics from Shihezi oasis hospital from February 2015 to May 2017 were collected and randomly divided into two groups.Two groups were given Olanzapine Tablets 10-20 mg/days,the experimental group （a total of 48 cases） combined with rTMS treatment 20 times, and the control group （52 cases） combined pseudo rTMS,that is,ineffective stimulation treatment 20 times. The efficacy evaluation tools were the PANSS scale and the WCST program. Results 1.after treatment in different ways,the total score of PANSS,positive symptom score, negative symptom score and psychopathology score of the two groups all declined.2.there were significant differences in the reduction rate of PANSS and negative symptom scores between the two groups （group vs,control group：40.8% vs30.1%,39.8% vsl 8.5%,P〈0.05）.The results of WCST test in 3. and two groups were significantly different from those before treatment （P〈0.05）.The difference between the two groups after treatment was statistically significant （P〈0.05）. Conclusion The combination of Olanzapine Tablets and rTMS can effectively improve the negative symptoms and cognitive function of first-episode schizophrenia, and provide a new method for early intervention and treatment of first-episode schizophrenia.

关 键 词：重复经颅磁刺激 首发精神分裂症 随机对照 

分 类 号：R749.3[医药卫生—神经病学与精神病学]