度洛西汀联合脑生物反馈仪治疗混合性焦虑和抑郁障碍的临床对照研究  

Duloxetine with brain biofeedback instrument therapy clinical control study of mixed anxiety and depression disorders

作　　者：刘静[1] 吴翥旗 刘永立[1] 王东明[1] 

机构地区：[1]包头市第六医院临床七科,内蒙古包头014040

出　　处：《临床医药文献电子杂志》2017年第37期7149-7150,7156,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的探讨度洛西汀联合脑生物反馈仪治疗混合性焦虑和抑郁障碍的临床疗效。方法选取我院2015年10月~2017年3月收治的门诊和病房诊断"混合性焦虑和抑郁障碍"的患者60例为研究对象。患者随机分为两组各30例,度洛西汀单独治疗组(A组),度洛西汀联合脑生物反馈仪治疗组(B组)。采用HAMA、HAMD评定两组患者治疗前及治疗后第2、4、6周的临床疗效。采用SPSS24.0软件分析数值,以P<0.05有统计学意义。结果 A、B组治疗前HAMA评分比较,差异无统计学意义(P>0.05),HAMD评分比较,差异无统计学意义(P>0.05)。比较A组治疗前后的HAMA,差异有统计学意义(P<0.05),HAMD,差异有统计学意义(P<0.05)。比较B组治疗前后的HAMA差异有统计学意义(P<0.05),HAMD差异有统计学意义(P<0.05)。比较A、B两组治疗后不同时间的疗效:HAMA2周,差异无统计学意义(P>0.05);HAMD2周,差异无统计学意义(P>0.05),示A、B两组治疗2周的疗效,差异无统计学意义;HAMA4周差异有统计学意义(P<0.05),HAMD4周差异有统计学意义(P<0.05),示A、B组治疗4周的疗效差异有统计学意义;HAMA6周差异有统计学意义(P<0.05),HAMD6周差异有统计学意义(P<0.05),示A、B组治疗6周的疗效差异有统计学意义。A、B组治疗后总疗效比较:HAMA总差异有统计学意义(P<0.05),HAMD总差异有统计学意义(P<0.05)。结论度洛西汀单独治疗和度洛西汀联合脑生物反馈仪治疗均有效。治疗2周两组患者的疗效无差异;治疗4周和6周度洛西汀联合脑生物反馈仪疗效优于度洛西汀单独治疗。度洛西汀联合脑生物反馈仪总疗效优于度洛西汀单独治疗。Objective To discuss the clinical efficacy of the combined brain biofeedback instrument in the treatment of mixed anxiety and depression. Methods Choose in October 2015-2017 3 menstrual baotou sixth hospital outpatient and ward diagnosis ／＂mixed anxiety and depression disorderV＇of 60 patients as the research object. Patients were randomly divided into two groups,duloxetine separate treatment group 30 cases （group A）, duloxetine joint brain biofeedback treatment group 30 cases （group B）.Using HAMA and HAMD rating in the two groups before and after treatment in patients with the clinical curative effect of the first 2.4.6 weeks.Said SPSS24.0 software analysis numerical （P〈0.05）. Results A and B groups before treatment HAMA score comparison （P〉0.05）, the HAMD score comparison （P〉0.05）, no statistical significance.HAMA comparison before and after treatment group A （P〈0.05）,HAMD （P〈0.05）,the difference had statistical significance.Comparison group B before and after treatment of HAMA （P〈0.05）,HAMD（P〈0.05）, the difference had statistical significance.Comparison of A and B two groups after treatment the curative effect of different time： HAMA2 weeks （P〉0.05）, HAMD2 weeks （P〉0.05）, and shown A, B two groups of treatment the curative effect of t^vo weeks there was no statistically significant difference;HAMA4 weeks （P〈0.05）, HAMD4 weeks （P〈0.05）, and shown A, B group of 4 weeks of treatment efficacy difference was statistically significant;HAMA6 weeks （P〈0.05）, HAMD6 weeks （P〈0.05）, and shown A, B group difference was statistically significant curative effect for the treatment of 6 weeks.A and B group after treatment the total curative effect comparison： HAMA total （P〈0.05）, the total HAMD （P〈0.05）, the difference was statistically significant. Conclusion The treatment of the individual therapy and the degree of the combined brain biofeedback instrument was effective. There was no difference in the treatment of two

关 键 词：度洛西汀 脑生物反馈 混合性焦虑和抑郁障碍 

分 类 号：R749[医药卫生—神经病学与精神病学]