口服四种维生素联合FE复合酶含漱治疗复发性口腔溃疡的疗效及对血清炎性因子水平的影响  

Clinical Effect of Four Oral Vitamins Combined with FE Complex Enzyme Rash on Recurrent Oral Ulcer and Serum Inflammatory Factors Levels

作　　者：赵军海[1] 韩浩[1] 李立刚[1] 王静[1] 张群娅[1] 

机构地区：[1]陕西中医药大学第二附属医院口腔科,陕西咸阳712000

出　　处：《现代生物医学进展》2017年第26期5096-5099,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(12003954)

摘　　要：目的:探讨口服四种维生素[维生素E(Vit E)+叶酸(FA)+维生素B2(Vit B2)+维生素B12(Vit B12)]联合FE复合酶含漱治疗复发性口腔溃疡(ROU)的临床效果及对患者血清炎性因子水平的影响。方法:选取我院2014年1月~2016年2月收治的126例ROU患者,采用随机数字表法均分为两组。对照组予以FE复合酶治疗,观察组在此基础上口服四种维生素(Vit E+FA+Vit B2+Vit B12)治疗。记录比较两组的局部疗效、远期疗效,治疗前后血清炎性因子水平以及不良反应的发生情况。结果:与对照组相比,观察组治疗30d后疼痛指数显著降低(P<0.01),平均溃疡期显著缩短(P<0.01)。治疗后6个月,观察组总有效率为95.2%,较对照组明显上升(81.0%,P<0.05)。与治疗前对比,两组治疗30 d后血清TNF-α、IL-17水平均显著降低(P<0.01),IL-2水平均显著升高(P<0.01);且观察组以上各炎性因子的改善效果均更为显著(P<0.01)。两组不良反应率对比差异无统计学意义(P>0.05)。结论:口服四种维生素联合FE复合酶含漱治疗复发性口腔溃疡更能有效促进溃疡创面愈合,减轻疼痛,调节机体促/抗炎因子平衡,提高远期治疗效果,且安全性高。Objective： To explore the clinical effect of four oral vitamins [vitamin E （Vit E） ＋ folio acid （FA）＋ vitamin B2 （Vit B2） ＋ vitamin B12 （Vit B12）] combined with FE complex enzyme rash on the recurrent oral ulcer （ROU） and on the serum inflammatory factors levels. Methods： 126 cases with ROU in our hospital from January 2014 to February 2016 were selected as research objectives and randomly divided into two groups. FE complex enzyme was provided to the control group, while FE complex enzyme and four Vietnam （Vit E＋FA＋Vit B2＋Vit B12） were given to the observation group. The local efficacy, long-term efficacy, serum inflammatory factor levels before and after treatment as well as the incidence of adverse drug reactions were recorded and compared between two groups. Results： Compared with the control group, the pain index was significantly decreased on 30th treating day in the observation group（P〈0.01）, and the average ulcer period was shorten （P〈0.01）. After being treated for 6 months, the overall effective rate was 95.2% in the observation group, which was significantly higher than that of the control group （81.0%, P〈0.05）. The serum TNF-α and IL-17 levels on the 30th treating day was significantly lower in both groups after treatment than those before treatment （P〈0.01）, but the serum IL-2 level was significantly increased （P〈0.01）, and the improvement of each above inflammatory factors in the observation group were more significant than those of the control group （P〈0.01）. No significant difference was found in the incidence of adverse reactions between two groups （P〉0.05）. Conclusions： Four oral Vietnam combined with FE complex enzyme could promote the ulcer wound healing, reduce the pain, regulate the body to promote/anti-inflammatory factor balance and improve the long-term efficacy in the treatment of patients with ROU with high safety.

关 键 词：复发性口腔溃疡 维生素 FE复合酶 炎性因子 

分 类 号：R781.5[医药卫生—口腔医学]