DNA羟甲基化修饰在消化系统肿瘤中的研究进展  

Research on DNA Hydroxymethylation Modification in Digestive System Carcinoma

作　　者：刘少卿[1] 屈丁丁 李卫萍[3] 何晨翔 张健[2] 郑建勇[1] 

机构地区：[1]第四军医大学西京消化病医院消化外科,陕西西安710032 [2]第四军医大学生物化学与分子生物学教研室,陕西西安710032 [3]陕西中医药大学第二附属医院脑病科,陕西西安712046

出　　处：《现代生物医学进展》2017年第26期5189-5193,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81572816);陕西省科技统筹创新工程计划项目(2015KTCQ03-02)

摘　　要：DNA羟甲基化修饰是基因组表观遗传学的重要调控方式,指5-甲基胞嘧啶(5-m C)在TET蛋白家族的催化作用下氧化生成5-羟甲基胞嘧啶(5-hm C),完成DNA胞嘧啶的去甲基化过程。基因组甲基化异常导致了多种肿瘤的发生,羟甲基化修饰作为去甲基化的一种,同样与肿瘤发生密不可分。在消化系统肿瘤发生发展过程中存在5-hm C含量的变化,其原因可能与TET蛋白家族、IDH突变等密切相关,提示DNA羟甲基化修饰参与了消化系统肿瘤的发生发展过程。本文围绕DNA羟甲基化修饰与消化系统肿瘤之间的关系进行综述,旨在为消化系统肿瘤羟甲基化修饰研究提供新方向。DNA hydroxymethylation modification is an important part of genome epigenetic regulation. The demethylation process from 5-methylcytosine （5-mC） to 5-hydroxymethyleytosine （5-hmC） is catalyzed by Tet protein. Abnormal genomic methylation leads to the occurrence of a variety of turnors. Hydroxymethylation is modified as a kind of demethylation and is inseparable from tumorigenesis. The expression of 5-hmC changes accompanied with the development and progression of digestive system tumors, which may be associated with the TET protein family and IDH mutation. It suggested that DNA hydroxymethylation is involved in the development and progression of digestive system tumors. This paper reviews the relationship between DNA hydroxymethylation and digestive system tumors, and aims to provide a new direction for the study of Hydroxymethylation modification in digestive system tumors.

关 键 词：羟甲基化 胃癌 肝癌 结直肠癌 食管癌 

分 类 号：R735[医药卫生—肿瘤]