疏肝法对肝郁型MCI患者认知功能、尿8-OHdG及血浆SOD和LPO的影响  

Effects of Soothing Liver Therapy on Cognitive Function,8-OHdG in Urinary and Plasma SOD and LPO in MCI Patients with Liver Qi Stagnation Type

作　　者：侯俊林[1] 詹向红[1] 孙前明[1] 关徐涛[1] 刘永[1] 梁鹤[1] 闫国立[1] 李伟[1] 

机构地区：[1]河南中医药大学,郑州450046

出　　处：《中国中医基础医学杂志》2017年第8期1102-1104,1128,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(81173148)-基于肝疏泄理论探讨情志对衰老进程中认知功能的影响及机制;国家自然科学基金资助项目(81473556)-疏肝法对情绪调节不良MCI患者工作记忆影响的机制研究;河南中医药大学博士科研基金项目(BSJJ2011-08)-孔圣枕中丹对MCI患者认知功能和ERP成分的影响

摘　　要：目的:探讨疏肝法对肝郁型MCI患者肝郁程度、认知功能、尿8-OHdG及血浆SOD和LPO的影响。方法:用国际MCI诊断标准和肝气郁结证症状筛选标准筛选40~65岁的肝郁型MCI患者,用肝气郁结证症状程度计分表对患者的肝气郁结程度进行评测,用MoCA量表和WAIS-RC量表简式对患者的认知功能进行评测,用ELISA法对患者用药前后的尿8-OHdG、血浆SOD和LPO进行检测。结果:与用药前比较,患者用药后肝气郁结证症状程度计分降低;MoCA量表的视空间与执行、注意、语言、抽象、延迟回忆、定向及总分均升高,命名得分无明显改变;WAIS-RC量表四合一简式的相似性、数字广度、填图、木块图和总分升高;8-OHdG含量降低,SOD及LPO值无明显变化。结论:疏肝法能降低肝郁型MCI患者的肝气郁结症状,改善患者的认知功能,降低DNA的氧化损伤是认知功能改善的可能原因。Objective： To study the effect of Shugan method to liver depression degree,cognitive function,8-OHdG,SOD and LPO in MCI patients with liver qi stagnation. Methods： Use the International diagnostic criteria for MCI and symptoms of liver qi stagnation screening standard to screening 40 to 65 years old MCI patients with liver qi stagnation. Use degree of liver qi stagnation scores table to evaluate patients degree of liver qi stagnation. Use MoCA and WAIS-RC to evaluating patients cognitive function. Use ELISA to detect 8-OHdG,SOD and LPO in patients before and after treatment.Results： Compared with before treatment,after treatment in the patients,score of liver qi stagnation symptom reduced,score of visuospatial execution,attention,language,abstract,delayed recall,orientation and total score of MoCA Scale all increased. Score of name of MoCA Scale did not change significantly. Score of similarity,digit span,mapping,block diagram and total score of WAIS-RC all increased. The content of 8-OHdG decreased. The activity of SOD and the content of LPO had no significant change. Conclusion： Shugan method can reduce symptoms of liver qi stagnation in MCI patients with liver qi stagnation,improve patients cognitive function,reduce oxidative damage to DNA is the possible causes of the improve of patients cognitive function.

关 键 词：疏肝法 肝气郁结 认知功能 氧化水平 

分 类 号：R229[医药卫生—中医基础理论]