中枢和周围神经系统联合脱髓鞘疾病的研究进展  

Recent advances in combined central and peripheral demyelination

作　　者：王芳[1] 姚源蓉 

机构地区：[1]天津医科大学总医院神经内科,天津300052 [2]贵州省人民医院神经内科,贵阳550002

出　　处：《中华神经医学杂志》2017年第9期966-969,共4页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金（81271409）

摘　　要：中枢和周围神经系统联合脱髓鞘疾病（CCPD）NI中枢神经系统和周围神经系统同时或相继发生脱髓鞘．是一种不同于单纯中枢神经系统脱髓鞘和周同神经系统脱髓鞘的新疾病体。CCPD的发病机制目前尚不清楚，可能与机体的免疫异常有关，其发病率低，临床表现多样，目前没有统一的诊断标准。本文将对CCPD的病因、发病机制、临床表现、特异的生物学标志物、影像学特征、治疗及预后等方而进行阐述，以提高大家对CCPD的认识和诊疗水平。Combined central and peripheral demyelination （CCPD） refers to the demyelination concurrently or sequentially occuring in the central and peripheral nervous systems. CCPD is a new disease entity, which is different from the independent central or peripheral nervous system demyelination. The pathogenesis of CCPD is unclear. The immune abnormalities may be involved. CCPD has low incidence, various manifestations, no specific biomarkers, and no uniform diagnostic criteria. This review summarizes the etiology, pathogenesis, clinical features, specific biomarkers, imaging characteristics, treatments and prognoses of CCPD to improve our understanding of CCPD.

关 键 词：中枢和周围神经系统联合脱髓鞘疾病 抗神经束蛋白155抗体 免疫异常 

分 类 号：R744.5[医药卫生—神经病学与精神病学]