乳酸锌和氟化亚锡对铜绿假单胞菌、鲍曼不动杆菌和变异链球菌生物被膜的抑制作用  

Anti-biofilm effects of Zn lactate·3H_2O and SnF_2 on Pseudomonas aeruginosa,Acinetobacter baumannii and Streptococcus mutans

作　　者：于珊 张妙坤 马旅雁[1] 

机构地区：[1]中国科学院微生物研究所,北京100101 [2]中国科学院大学,北京100049

出　　处：《生物工程学报》2017年第9期1478-1488,共11页Chinese Journal of Biotechnology

基　　金：国家重点基础研究发展计划(973计划)(No.2014CB846002);国家自然科学基金(No.31570126);北京宝洁技术有限公司资助~~

摘　　要：乳酸锌(Zn lactate·3H_2O)和氟化亚锡(SnF_2)常作为牙膏中的活性物质添加剂用来预防龋齿及口腔生物被膜的形成。文中评估了Zn lactate·3H_2O和SnF_2对铜绿假单胞菌、鲍曼不动杆菌和变异链球菌生物被膜的作用。对铜绿假单胞菌PAO1生物被膜的抑制实验证实乳酸锌和氟化亚锡都具有抑制其生物被膜的功能,联用效果尤佳。乳酸锌通过干扰胞外多糖基质网的形成起作用,而氟化亚锡则可以明显降低生物被膜的生物量。更为重要的是,工作浓度的两种化合物联用几乎可以完全抑制3种实验菌株生物被膜的形成。Zn lactate and SnF2 were used as active compounds in the dentifrice. Here, their antl-blotilm ettects were evaluated on Pseudomonas aeruginosa, Acinetobacter baumannii and Streptococcus mutans. The biofilm prevention/ dispersal assay of P. aeruginosa PAO1 demonstrated that Zn lactate and SnF2 can inhibit biofilm formation independently or by combined treatment. Zn lactate disrupted extracellular polysaccharides matrix formation and SnF2 reduced the biomass of biofilm. Most importantly, the combination of Zn lactate and SnF2 thoroughly abolished the biofilm formation of all three strains.

关 键 词：铜绿假单胞菌 乳酸锌 氟化亚锡 生物被膜 鲍曼不动杆菌 变异链球菌 

分 类 号：R78[医药卫生—口腔医学] TQ658.41[医药卫生—临床医学]