奈达铂、顺铂联合同期放疗治疗局部中晚期宫颈癌的疗效及急性毒副反应比较  

Comparison of efficacy and acute toxicity between nedaplatin and cisplatin combined with concurrent radiotherapy for locally mid-term and advanced cervical cancer

作　　者：廖思辉 王芳芳 陈运强 马昌承 LIAO Si-hui WANG Fang-fang CHEN Yun-qiang MA Chang-cheng(Department of Radiotherapy, the Ninth Affiliated Hospital of Guangxi Medical University ＆ Beihai People＇s Hospital, Beihai 536000, Chin)

机构地区：[1]广西医科大学第九附属医院暨北海市人民医院放疗科,北海市536000

出　　处：《广西医学》2017年第9期1328-1331,共4页Guangxi Medical Journal

基　　金：广西医药卫生科研课题(Z2012010)

摘　　要：目的比较奈达铂、顺铂联合同期放疗治疗局部中晚期宫颈癌的近、远期疗效及急性毒副反应。方法选择Ⅱb~Ⅲb期宫颈癌患者80例,随机分为奈达铂组和顺铂组各40例。两组患者均采用盆腔外照射联合腔内照射进行放疗,分别采用奈达铂和顺铂进行同期化疗。比较两组患者的治疗有效率、1年及2年生存率、无瘤生存率及急性毒副反应发生情况。结果两组的总有效率、1年及2年总生存率、1年及2年无瘤生存率比较,差异均无统计学意义(均P>0.05)。奈达铂组患者白细胞减少的发生比例高于顺铂组,而食欲减退、恶心呕吐的发生比例低于顺铂组(P<0.05)。结论奈达铂联合同期放疗治疗局部中晚期宫颈癌的近、远期疗效与顺铂联合同期放疗相当,但患者对奈达铂具有更好的耐受性。Objective To compare the short-term/long-term clinical efficacy and acute toxicity between nedaplatin and cisplatin combined with concurrent radiotherapy for locally mid-term and advanced cervical cancer .Methods Eighty patients with stage Ⅱb-Ⅲb cervical cancer were randomly divided into nedaplatin group and cisplatin group ,with 40 cases in each group .Both groups received external radiation of pelvic cavity and intracavitary therapy for radiotherapy .Concurrent chemotherapy using nedaplatin and cisplatin were conducted in the nedaplatin group and cisplatin group respectively .The therapeutic effective rate ,1-and 2-year survival rates ,disease-free survival rate and incidence of acute toxicity were compared between the two groups .Results There were no statistically significant differences in the therapeutic effective rate,1-and 2-year survival rates,or 1-and 2-year disease-free survival rates between the two groups （all P〉0.05）. The proportion of patients with leukopenia was higher ,and the proportions of patients with anorexia ,nausea and vomiting were lower in the nedaplatin group compared to the cisplatin group （P〈0.05）.Conclusion For locally mid-term and advanced cervical cancer ,nedaplatin combined with concurrent radiotherapy obtains similar short-and long-term clinical efficacy as cisplatin combined with concurrent radiotherapy.However,the patients achieve better tolerance of nedaplatin .

关 键 词：宫颈癌 奈达铂 顺铂 同期放疗 毒副反应 

分 类 号：R737.33[医药卫生—肿瘤]