低频重复经颅磁刺激对妊娠期抑郁症治疗及影响研究  

THE CURATIVE EFFECTS OF LOW-FREQUENCY REPETITIVE TRANSC-RANIAL MAGNETIC STIMULATION ON GESTATION DEPRESSION

作　　者：沈秀梅[1] 王志广[1] SHEN Xiu-mei WANG Zhi-guang(Linyi City Mental Center, Linyi 276005, Chin)

机构地区：[1]临沂市精神卫生中心,山东临沂276003

出　　处：《山东医学高等专科学校学报》2017年第4期270-272,共3页Journal of Shandong Medical College

摘　　要：目的探讨低频重复经颅磁刺激(rTMS)对妊娠期抑郁症的疗效及副反应。方法将35例妊娠期患抑郁症的患者给予右侧前额叶低频TMS治疗,在治疗前、治疗1周末、2周末、3周末、4周末进行汉密尔顿量表(HAMD)评定,使用副反应量表(TESS)于治疗后1周末、2周末、4周末评定副反应。对孕妇及胎儿进行密切监护,对孕妇分娩及新生儿进行随访。结果 HAMD评分:治疗3周后差异有显著性(P<0.05),治疗4周后差异有极其显著性(P<0.01)。总体疗效:痊愈8例(22.8%),好转15例(42.8%),无效12例(34.2%)。副反应轻微,对孕妇及胎儿无明显影响。结论 rTMS对妊娠期抑郁症疗效较好,对孕妇及胎儿无明显副作用。Objective To explore the curative effect of low-frequency repetitive transcranial magnetic stimulation （rTMS） on gestation depression. Methods 35 patients were treated with low-frequency rTMS for 4 weeks. The curative effect and side effects were assessed with Hamilton rating scale （HAMD） before treatment, and one, two, three and four weeks after treatments. The side effects were assessed with the Treatment Emergent Symptom Scale （TESS） one, two and four weeks after treatments. The pregnant women and fetuses were closely observed and the follow-up surveys were conducted. Results After 3 and 4 weeks of treatment, the decline of HAMD scores was statistically significant（ P 〈0.05 and P 〈0.01）. The curative rate, the improvement rate and zero-effect rate were 22.8%, 42.8% and 34.2% respectively. The side effects of low-frequency rTMS were slight. Conclusion Low-frequency repetitive transcranial magnetic stimulation （rTMS） can produce good curative effect on gestation depression.

关 键 词：妊娠期抑郁症 低频 重复经颅磁刺激 治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]