机构地区:[1]蚌埠市第三人民医院神经内科,安徽蚌埠233000
出 处:《医学综述》2017年第18期3740-3744,共5页Medical Recapitulate
摘 要:目的探讨血浆D-二聚体、纤维蛋白原(Fib)和血清高敏C反应蛋白(hs-CRP)与急性脑梗死(ACI)严重程度的相关性。方法随机抽取2015年1月至2016年8月于蚌埠市第三人民医院神经内科住院的113例ACI患者,并选取同期健康体检者100例作为正常对照组,ACI组患者于入院24 h内检测血浆D-二聚体、Fib和血清hs-CRP水平,正常对照组于体检当日检测三者水平,分析三者与ACI面积、神经功能缺损程度的相关性。结果113例ACI患者中轻度组53例,中度组40例,重度组20例;腔隙性梗死39例,小面积梗死48例,大面积梗死26例。(1)ACI患者D-二聚体、Fib和hs-CRP水平均高于正常对照组[(1.74±1.98)mg/L比(0.25±0.10)mg/L,(4.69±0.90)g/L比(2.64±0.56)g/L,(32.10±50.02)mg/L比(1.98±0.83)mg/L](P<0.01)。(2)重度组D-二聚体、Fib和hs-CRP水平分别为(1.89±0.06)mg/L、(6.60±0.36)g/L、(112.54±76.78)mg/L。中度梗死组及重度梗死组患者血清D-二聚体、Fib和hs-CRP均高于轻度梗死组(P<0.01)。重度梗死组血清D-二聚体、Fib和hs-CRP也明显高于中度梗死组(P<0.01)。(3)大面积脑梗死组D-二聚体、Fib和hs-CRP水平分别为(1.68±0.06)mg/L、(6.39±0.35)g/L、(110.50±71.18)mg/L。小面积梗死组及大面积梗死组患者血清D-二聚体、Fib和hs-CRP均高于腔隙性梗死组(P<0.01)。大面积梗死组血清D-二聚体、Fib和hs-CRP也明显高于小面积梗死组(P<0.01)。(4)D-二聚体、Fib和hs-CRP与ACI患者神经功能损伤程度和梗死面积呈正相关(P<0.001)。结论ACI患者梗死面积越大、神经功能损伤程度越重,D-二聚体、Fib和hs-CRP越高。D-二聚体、Fib和hs-CRP与ACI患者神经功能损伤程度和梗死面积呈正相关。Objective To explore the correlation between plasma D - dimer, fibrinogen(Fib) , and serum high-sensi- tive C-reactive protein(hs-CRP) and the severity of acute cerebral infarction(ACI). Methods A total of 113 ACI inpa- tients were randomly selected from Jan. 2015 to Aug. 2016 in the Department of Neurology of the Third People's Hospital of Bengbu, 100 cases of healthy check-up were chosen as a normal control group. Plasma D-dimer, Fib and serum hs-CRP level was tested within 24 hours after admission, or on the examination day level detection, and correlation between them and ACI area and degree of neurological function impairment was analyzed. Results Of the 113 ACI patients,53 cases were in the mild group, 40 cases were in the moderate group, 20 eases were in the severe group. There were 39 cases of la- cunar infarction, 48 cases of small area infarction, 26 cases of large infarction. ①D-dimer, Fib dimer and hs-CRP levels of ACI patients were higher than those of normal control group [ ( 1.74 ± 1.98 ) mg/L vs ( 0.25±0. 10 ) mg/L, ( 4.69 ± 0.90) g/Lvs (2.64±0.56) g/L,(32.10+50.02) mg/L vs (1.98 ±0.83) mg/L](P〈0.0). ②The levels of D-dimer, Fib and hs-CRP in the severe group were ( 1.89±0.06) mg/L, (6.60 ±0. 36) g/L, ( 112.54±76.78) rag/L, respectively. The serum D-dimer, Fib and bs-CRP in the moderate group and the severe group were higher than those in the mild group (P 〈0.01 ). The serum D-dimer, Fib and hs-CRP in the severe group were significantly higher than those in the moderate group (P 〈 0. 01 ). ③The levels of D-dimer, Fib, and hs-CRP in the large cerebral infarction group were ( 1.68 ± 0.06) rag/L, (6.39 ± 0.35 ) g/L, ( 110.50 ± 71.18) mg/L. The serum D-dimer, Fib and hs-CRP in the small infarct group and the large infarct group were higher than those in the lacuhar infarction group ( P 〈 0. 01 ). The serum D-dimer, Fib and hs-CRP in the large infarct group were significantly higher than those in the
关 键 词:急性脑梗死 D-二聚体 纤维蛋白原 高敏C反应蛋白
分 类 号:R743.3[医药卫生—神经病学与精神病学]
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