社区轻度认知障碍老人共病抑郁情绪认知功能变化的随访研究  

Cognitive function changes of the elderly residents with mild cognitive impairment combined with depression in community: one year follow-up

作　　者：钟盈花[1] 秦虹云[1] 张明[1] ZHONG Yinghua QIN Hongyun ZHANG Ming(Shanghai Pudong New Area Mental Health Center, Shanghai 200124, China)

机构地区：[1]上海市浦东新区精神卫生中心,上海200124

出　　处：《中国民康医学》2017年第11期4-6,51,共4页Medical Journal of Chinese People’s Health

基　　金：基金项目:张明浦东新区名中医及中医工作室建设(PDZYXK-3-2014007)

摘　　要：目的:探讨社区轻度认知障碍(Mild Cognitive Impairment,MCI)老人共病抑郁情绪的认知功能随访一年后的变化特征。方法:选取MCI老年患者90例为研究对象,分为抑郁组(伴抑郁情绪,18例)及对照组(不伴有抑郁情绪,72例)。分别于入组时和一年后对受试者进行简易智力状态检查量表(Mini-mental State Examination,MMSE)、蒙特利尔认知评估量表(Montreal Cognitive Assessment,Mo CA)评分。结果:入组一年后,抑郁组的注意力和计算力因子分升高,而对照组下降,两组比较差异有统计学意义(P<0.05),但两组患者的MMSE总分比较,差异无统计学意义(P>0.05)。与对照组比较,抑郁组的注意力、定向因子分及Mo CA总分较入组时升高,差异均有统计学意义(P<0.05)。结论:MCI患者伴抑郁情绪随访一年后总体认知功能没有减退,反而较对照组有所提高,抑郁情绪是否促使MCI认知功能减退仍有待于进一步研究。Objective： To investigate changes of cognitive function of the elderly residents with mild cognitive impairment （ MCI ） combined with depression in community through one year follow-up. Methods ： A total of 90 elderly patients with MCI were se- lected and divided into depression group （ combined with depression, n = 18 ） and control group （ without depression, n = 72 ）. All these patients were assessed with mini-mental state examination （MMSE） and Montreal cognitive assessment scale （MoCA） before and one year after entering into the group. Results ： One year after entering the group, the scores of attention and computational power fac- tors of the depression group increased, while those of the control group decreased, and the differences between the two groups were sta- tistically significant （P〈0.05）. However, the difference of the total scores of MMSE between the two groups were not statistically sig- nificant （ P〉0.05 ）. Compared with the control group, the scores of the attention and orientation factors and the MoCA total score of the depression group were higher than those before entering the group, and the differences were statistically significant （ P〈0.05 ）. Con- clusions ： The overall cognitive function of the depression group does not decrease after the one-year follow-up study, but is better than that of control group. Therefore, whether depression could induce the cognitive decline still needs further studies.

关 键 词：轻度认知障碍 抑郁情绪 认知功能变化 

分 类 号：R749.16[医药卫生—神经病学与精神病学]