硒抗肿瘤机理研究进展和展望  

Progress and Prospects of Selenium Anti-tumor Mechanism

作　　者：鲍鹏 李国祥 BAO Peng LI Guoxiang(Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Fujian Xiamen 361021, China Ningbo Urban Environment Observation and Research Station, Chinese Academy of Sciences, Zhejiang Ningbo 315830, China University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院城市环境研究所城市环境与健康重点实验室福建,厦门361021 [2]中国科学院宁波城市环境观测研究站,浙江宁波315830 [3]中国科学院大学,北京100049

出　　处：《生物技术进展》2017年第5期506-510,共5页Current Biotechnology

基　　金：国家自然科学基金项目(41571240);宁波市科技惠民项目(2017C50009)资助

摘　　要：作为一种参与生命活动的重要营养元素,硒具有普遍的防癌、抗癌作用。迄今为止对于硒抗肿瘤机理的研究已经得出了众多结论。综述了硒元素的抗肿瘤效用和机理,并重点探讨了最新的研究结论——亚硒酸钠暴露的肿瘤细胞内可以发生亚硒酸钠还原并与细胞内蛋白结合自组装产生纳米硒粒子。这一研究结果很好的解释了超大剂量硒的多重毒理效应以及硒对产生耐受性的肿瘤抑制增强效应。对于肿瘤细胞/组织内自生纳米硒粒子的进一步研究将有望揭示硒元素抗肿瘤的潜藏机制,形成对于硒元素抗肿瘤机理的统一认识。As an important nutrient element that participate in the activities of life, selenium （Se） has general prevention and anti-cancer effects. So far, variety opinions were concluded on Se anti-tumor mechanism. This paper reviewed the progress on anti-tumor effects and mechanisms of Se, and highlighted the latest study founding, that sodium selenite exposure could occur selenite reduction to elemental Se, and combined with intracellular protein for self-assembly of Se nanoparticles within the tumor cells. The results well explained the multiple toxicology effect of Se with large dose and the enhanced inhibition effect to radiation and chemotherapy tolerance tumors. The further study of the Se nanoparticles in tumor cells/tissues will reveal the underlying anti-tumor mechanisms of Se, and form an unified understanding of Se anti-tumor mechanisms.

关 键 词：硒 内自生纳米硒粒子 多重毒理效应 超大剂量 肿瘤耐受性 

分 类 号：R730.5[医药卫生—肿瘤]