Topological effects of macrocyclic polymers:from precise synthesis to biomedical applications  

作　　者：Jinming Hu Shiyong Liu 

机构地区：[1]Key Laboratory of Soft Matter Chemistry,Chinese Academy of Sciences,Hefei National Laboratory for Physical Sciences at the Microseale,iChem(Collaborative Innovation Center of Chemistry for Energy Materials),Department of Polymer Science and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《Science China Chemistry》2017年第9期1153-1161,共9页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(51690150,51690154,21674103,51673179);International S&T Cooperation Program of China of MOST(2016YFE0129700)

摘　　要：Polymer chain architectures play a crucial role in the physical properties of polymers and this unique phenomenon has been recognized as the topological effects.As one of the most representative architectures,macrocyclic polymers characterized by the endless topology have received extensive attention due to their distinct physical properties as compared to the linear counterparts.To understand these differences and unravel the underlying mechanisms,there is a long pursuit to efficiently fabricate macrocyclic polymers.To date,both ring-closing and ring-expansion strategies have been developed,which drastically elevates the accessibility of macrocyclic polymers.The improved availability of macrocyclic polymers enables the further investigation of the biomedical applications and the preliminary results suggest that macrocyclic polymers outperform their linear analogs in terms of improving gene delivery efficiency,elevating blood circulation time,and enhancing colloidal stability of nanoparticles.Polymer chain architectures play a crucial role in the physical properties of polymers and this unique phenomenon has been recognized as the topological effects.As one of the most representative architectures,macrocyclic polymers characterized by the endless topology have received extensive attention due to their distinct physical properties as compared to the linear counterparts.To understand these differences and unravel the underlying mechanisms,there is a long pursuit to efficiently fabricate macrocyclic polymers.To date,both ring-closing and ring-expansion strategies have been developed,which drastically elevates the accessibility of macrocyclic polymers.The improved availability of macrocyclic polymers enables the further investigation of the biomedical applications and the preliminary results suggest that macrocyclic polymers outperform their linear analogs in terms of improving gene delivery efficiency,elevating blood circulation time,and enhancing colloidal stability of nanoparticles.

关 键 词：MACROCYCLIC ring-closing RING-EXPANSION blood circulation time gene delivery colloidal stability 

分 类 号：O631[理学—高分子化学]