Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics  

作　　者：Jie Gao Maria Sanchez-Purra Hao Huang ShunhaoWang Yunan Chen Xuefeng Yu Qian Luo Kimberly Hamad-Schifferli Sijin Liu 

机构地区：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China [2]University of Chinese Academy of Sciences.Beijing 100049,China [3]Department of Engineerfng,University of Massachusetts Boston,Boston,MA 02125,United States [4]Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [5]Department of Mechanical Engineering,Massachusetts Institute of Technology,Cambridge,MA 02139,United States

出　　处：《Science China Chemistry》2017年第9期1219-1229,共11页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program(2014CB932000);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14000000);the National Natural Science Foundation of China(21425731,21637004)

摘　　要：Gold nanoparticles(AuNPs) have been attractive for nanomedicine because of their pronounced optical properties.Here,we customerized the methods to synthesize two types of gold nanostars,Au nanostars-1 and Au nanostars-2,which have different spire lengths and optical properties,and also spherical AuNPs.Compared to nanospheres,gold nanostars were less toxic to a variety of cells,including macrophages.Au nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that of nanospheres,and but reveled less liver retention than nanospheres.Due to their strong absorption in the near-infrared(NIR),Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm,and elicited a robust photothermal therapy(PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer cells.Meanwhile,Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy(SERS) in 4T1 cells.Our combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy.Gold nanoparticles (AuNPs) have been attractive for nanomedicine because of their pronounced optical properties. Here, we customerized the methods to synthesize two types of gold nanostars, Au nanostars-1 and Au nanostars-2, which have different spire lengths and optical properties, and also spherical AuNPs. Compared to nanospheres, gold nanostars were less toxic to a variety of cells, including macrophages. Au nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that of nanospheres, and but reveled less liver retention than nanospheres. Due to their strong absorption in the near-infrared (NIR), Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm, and elicited a robust photothermal therapy (PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer cells. Meanwhile, Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy (SERS) in 4T1 cells. Our combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy.

关 键 词：GOLD nanoparticle  nanostar  surface PLASMON resonance  tissue distribution  TOXICITY profile 

分 类 号：O614.123[理学—无机化学] TB383.1[理学—化学]