肿瘤相关巨噬细胞介导的炎性微环境对肝癌干细胞影响的研究进展  

Progress in influence of inflammatory microenvironment mediated by tumor-associated macrophages on liver cancer stem cells

作　　者：陈永旭 王昌俊[2] 

机构地区：[1]华南理工大学医学院,广东广州510006 [2]广东省人民医院广东省医学科学院广东省老年医学研究所,广东广州510080

出　　处：《肿瘤》2017年第9期989-994,共6页Tumor

基　　金：国家自然科学基金资助项目(编号:81373582);广东省自然科学基金资助项目(编号:S2013010012636)~~

摘　　要：肝癌的发展和肝炎病毒引起的炎性反应有关,巨噬细胞是慢性炎性反应中最主要的细胞之一。活化的M2型巨噬细胞能分泌一系列炎性反应因子,参与炎性微环境的调节,从而导致肝癌干细胞的形成。本文将就肿瘤相关巨噬细胞和肿瘤干细胞之间的关系进行综述,以期从靶向肿瘤相关巨噬细胞的角度为肿瘤的防治提供一条新的思路。The development of liver cancer is associated with the inflammation caused by hepatitis virus. Macrophages are one of the most important cells in chronic inflammation response.The activated M2-type macrophages can secrete a series of inflammatory factors to participate in there gulation of inflammatory micro environment, and lead to the formation of liver cancer stem cells. In this review, the relationship between tumor-associated macrophages and cancer stem cells is discussed, in order to provide a new idea for the prevention and treatment of tumor.

关 键 词：肝肿瘤 肿瘤微环境 巨噬细胞 肿瘤干细胞 

分 类 号：R735.7[医药卫生—肿瘤]