盐酸哌甲酯缓释片对注意缺陷多动障碍患儿认知加工过程的影响  

Influence of Methylphenidate Hydrochloride prolonged - release tablets on the cognitive processing of children with attention deficit hyperactivity disorder

作　　者：刘海润[1] 秦岭[1] 张鸿[1] 傅燕虹[1] 李丹丹[1] 姚春玲 梁正友[2] 

机构地区：[1]广西壮族自治区人民医院认知睡眠中心,南宁530021 [2]广西大学计算机与电子信息学院,南宁530004

出　　处：《中华实用儿科临床杂志》2017年第17期1326-1330,共5页Chinese Journal of Applied Clinical Pediatrics

基　　金：广西科学研究与技术开发计划课题（桂科攻）（1355005-5-5）

摘　　要：目的探究盐酸哌甲酯缓释片治疗对注意缺陷多动障碍（ADHD）患儿认知加工过程的影响。方法选取接受盐酸哌甲酯缓释片治疗（28±3）d的30例ADHD患儿为ADHD组，同时选取30例健康儿童为健康对照组，采用Das—Nagliefi认知评估系统（DN：CAS）对ADHD组在治疗前、治疗后及健康对照组儿童进行大脑认知加工过程测验，比较ADHD组在治疗前及治疗后与健康对照组认知加工过程的差异，同时比较ADHD组在治疗前后认知加工过程的差异。结果与健康对照组比较，ADHD组治疗前DN：CAS测验中的计划分测验[（21．86±4．61）分比（29．33±5．06）分]、注意分测验[（25．00±4．57）分比（29．83±3．79）分]及总分[（111．93±13．95）分比（127．26±15．53）分]的量表分降低，差异均有统计学意义（t=-5．976、-4．455、-4．023，均P〈0．05）；数字匹配、计划编码、计划链接、表达性注意、数字检测、接受性注意6个小测验量表分均降低，差异均有统计学意义（t=-4．787、-3．703、-4．991、-2．216、-2．488、-3．219，均P〈0．05）。ADHD组治疗后DN：CAS测验中的计划分测验量表分仍低于健康对照组[（25．53±4．98）分比（29．33±5．06）分]，差异有统计学意义（t=-2．931，P〈0．05），数字匹配、计划编码2个小测验量表分仍低于健康对照组，差异均有统计学意义（t=-2．654、-2．044，均P〈0．05）。ADHD组治疗后DN：CAS测验中的计划分测验[（25．53±4．98）分比（21．86±4．61）分]、同时性加工分测验[（36．10±7．10）分比（34．13±6．04）分]、注意分测验[（27．90±5．69）分比（25．00±4．57）分]及总分[（121．50±16．55）分比（111．93±13．95）分]均高于治疗前，差异均有统计学意义（t=-5．679、-2．949、-3．869、-5．963，均P〈0．05）；数字匹配、计划编码、计划链接、非言语矩阵、数字检测、接受性�Objective To explore the influence of Methylphenidate Hydrochloride prolonged - release tablets on the cognitive processing of children with attention deficit hyperactivity disorder （ADHD）. Methods Thirty ADHD children and 30 healthy controls were enrolled in this study, and the ADHD subjects were treated with Methylphenidate Hydrochloride prolonged - release tablets for （ 28 ± 3） days. Pre - test and post - test by the Das - Naglieri ： Cognitive Assessment System（ DN ：CAS） were done to evaluate the cognitive function of all individuals. The differences of cogni- tive processing in pre - treatment and post - treatment of ADHD group with healthy control group were compared. The difference between before and after treatment of ADHD was also compared. Results Compared with healthy control group,there were lower of planning score [ （21. 86 ± 4.61 ） scores vs. （29.33 ± 5.06） scores], attention score [ （25.00 ± 4.57 ） scores vs. （ 29.83 ＋ 3.79） scores ], and the total scores [ （ 111.93 ± 13.95 ） scores vs. （ 127.26 ± 15.53） scores [ in ADHD group, and there were significant differences （ t = - 5. 976, - 4. 455, - 4. 023, all P 〈 0.05 ）. The matching number, planned codes, planned connections, expressive attention, number detection and receptive attention scores were also lower in ADHD group, and there were significant differences （t = -4. 787, -3. 703, - 4. 991, - 2. 216, - 2. 488, - 3. 219, all P 〈 0.05）. Compared with healthy control group, there were lower of plan- ning score with significant difference [ （ 25.53 ± 4.98 ） scores vs. （ 29.33 ± 5.06 ） scores, t = - 2.931, P 〈 0.05 ] in ADHD group after treatment, matching number and planned codes were lower with significant difference （ t = - 2. 654, - 2. 044, all P 〈 0.05 ） in ADHD group after treatment. In ADHD group, the scores of planning [ （ 25.53 ± 4.98 ） scores vs. （21.86 ＋ 4.61 ） scores ], simultaneous processing [ （ 56.10 ± 7. 10 ） scores vs. （34.13 ± 6.04 ） s

关 键 词：盐酸哌甲酯缓释片 Das—Naglieri认知评估系统 注意缺陷多动障碍 认知加工过程 

分 类 号：R749.94[医药卫生—神经病学与精神病学]