应用两种不同核黄素溶液的离子导入交联治疗进展期圆锥角膜后基质分界线深度比较  

Comparison of depth of demarcation line in iontophoresis-assisted corneal crosslinking using different riboflavin solution for progressive keratoconus

作　　者：贾洪真[1] 庞旭[1] 李刚[1] 李娜[1] 隋艳来 樊郑军[1] 彭秀军[1] JIA Hongzhen PANG Xu LI Gang LI Na SUI Yanlai FAN Zhengjun PENG Xiujun(Department of Ophthalmology, Navy General Hospital, Beijing 100048, China)

机构地区：[1]海军总医院眼科,北京100048

出　　处：《解放军医学院学报》2017年第9期824-826,849,共4页Academic Journal of Chinese PLA Medical School

基　　金：北京市科技计划资助项目(Z151100004015217)~~

摘　　要：目的比较应用0.1%核黄素蒸馏水溶液的离子导入交联与应用0.1%核黄素乳酸钠林格液的离子导入交联治疗进展期圆锥角膜后基质分界线的深度。方法选取2013年1月-2013年7月行0.1%核黄素乳酸钠林格液离子导入交联治疗进展期圆锥角膜11例患者16眼和2013年8月-2015年11月行0.1%核黄素蒸馏水溶液离子导入交联治疗进展期圆锥角膜62例患者78眼的眼科资料。比较治疗1个月后两组前节OCT检查的基质分界线深度。结果 0.1%核黄素乳酸钠林格液离子导入角膜交联组分界线深度为(268.25±18.06)μm,0.1%核黄素蒸馏水溶液离子导入角膜交联组分界线深度为(298.95±51.97)μm,差异有统计学意义(t=3.594,P=0.001)。两组分界线发生数量分别为9眼(9/16)和65眼(65/78),差异有统计学意义(χ~2=5.514,P=0.019)。结论 0.1%核黄素蒸馏水溶液离子导入角膜交联治疗进展期圆锥角膜效果可能优于0.1%核黄素乳酸钠林格液离子导入角膜交联。Objective To compare the depth of demarcation line in iontophoresis-assisted corneal crosslinking（I-CXL） using 0.1% riboflavin-distilled water solution versus in I-CXL using 0.1% riboflavin-sodium lactate Ringer＇s solution for progressive keratoconus. Methods From January to July in 2013, clinical data about 11 patients（16 eyes） treated with I-CXL using 0.1% riboflavin-sodium lactate Ringer＇s solution were collected; and from August 2013 to November 2015, clinical data about 62 patients（78 eyes） treated with I-CXL using 0.1% riboflavin-distilled water solution were collected. Anterior segment OCT was used to examine the depth of demarcation line and they were compared between two groups at 1 month after treatment. Results The depth of demarcation line was（268.25±18.06） μm in patients treated by I-CXL using 0.1% riboflavin-sodium lactate Ringer＇s solution, and it was（298.95±51.97） μm in patients treated by I-CXL using 0.1% riboflavin-distilled water with statistically significant difference between two groups（t=3.594, P=0.001）. The incidences of demarcation line in the two groups were 56.3% and 83.1% respectively, and the difference was statistically significant（χ^2=5.514, P=0.019）. Conclusion The efficacy of I-CXL using 0.1% riboflavindistilled water solution is better than that of I-CXL using 0.1% riboflavin-sodium lactate Ringer＇s solution for progressive keratoconus.

关 键 词：进展期圆锥角膜 角膜交联 离子导入 核黄素 

分 类 号：R779.6[医药卫生—眼科]