206例酒精性肝病患者的临床特点  

Clinical features of alcoholic liver disease: a clinical analysis of 206 cases

作　　者：高广甫 张淑凤[1] 王长武[1] 高红伟[1] GAO Guangfu ZHANG Shufeng WANG Changwu et al.(Department of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450005, Chin)

机构地区：[1]郑州大学第五附属医院消化内科,郑州450005

出　　处：《临床肝胆病杂志》2017年第9期1766-1768,共3页Journal of Clinical Hepatology

摘　　要：目的探讨酒精性肝病的临床特征,为其防治策略的制订提供理论依据。方法收集2011年1月-2016年12月郑州大学第五附属医院收治的206例酒精性肝病患者的临床资料。分析不同酒精性肝病的构成情况以及2011-2016年酒精性肝病占所有肝病患者的比例及其变化趋势;分析各种酒精性肝病患者的年龄分布特点;对比2011-2013年和2014-2016年前后3年各种酒精性肝病的构成情况。计数资料组间比较采用χ~2检验。结果酒精性肝硬化占比69.90%(144/206),其次为酒精性肝炎,占19.42%。2011-2016年酒精性肝病占同期住院肝病患者的比例呈现逐年上升的趋势。40~60岁年龄段酒精性肝病的发病率最高,为66.99%(138/206);酒精性脂肪肝以40~60岁年龄段的发病率最高,>60岁年龄段的发病率显著低于其他年龄段(χ~2=8.16,P=0.01);40~60岁年龄段酒精性肝炎占比18.84%(26/138),酒精性肝硬化占比68.84%(95/138),酒精性慢加急性肝衰竭占比5.07%(7/138)。2014-2016年收治的酒精性肝病患者中,酒精性肝硬化占比显著高于2011-2013年酒精性肝硬化患者所占比例(73.20%vs 60.38%,χ~2=9.24,P<0.05)。结论酒精性肝病好发于40~60岁人群,临床应当加强酒精性肝病的早期诊治,延缓或逆转肝纤维化及肝硬化发生。Objective To investigate the clinical features of alcoholic liver disease,and to provide a theoretical basis for the development of control strategy for this disease. Methods The clinical data of 206 patients with alcoholic liver disease who were admitted to The Fifth Affiliated Hospital of Zhengzhou University from January 2011 to December 2016 were collected. The different types of alcoholic liver disease were analyzed,as well as the proportion of patients with alcoholic liver disease among all patients with liver diseases and its change trend from 2011 to 2016. The age distribution characteristics of patients with different types of alcoholic liver disease were analyzed,and the types of alcoholic liver disease in 2011-2013 were compared with those in 2014-2016. The chi-square test was used for comparison of categorical data between groups. Results The patients with alcoholic cirrhosis accounted for 69. 90%（ 144/206）,followed by those with alcoholic hepatitis（ 19. 42%）. The proportion of patients with alcoholic liver disease among all patients with liver diseases gradually increased from 2011 to 2016. Of all patients with alcoholic liver disease,the patients aged 40-60 years accounted for 66. 99%（ 138/206）. Patients aged 40-60 years had the highest incidence rate of alcoholic fatty liver disease,and those aged 60 years had a significantly lower incidence rate than the other patients（ χ~2= 8. 16,P = 0. 01）. Of all the patients aged 40-60 years,18. 84%（ 26/138） had alcoholic hepatitis,68. 84%（ 95/138）had alcoholic cirrhosis,and 5. 07%（ 7/138） had alcoholic acute-on-chronic liver failure. Among the patients with alcoholic liver disease who were admitted from 2014 to 2016,73. 20% had alcoholic cirrhosis,which was significantly higher than the proportion of patients with alcoholic cirrhosis（ 60. 38%） from 2011 to 2013（ χ~2= 9. 24,P〈0. 05）. Conclusion Alcoholic liver disease is commonly seen in patients aged40-60 years. Early diagnosis of alcoholic liver disease should be enhan

关 键 词：肝疾病 酒精性 疾病特征 

分 类 号：R575[医药卫生—消化系统]