延长油田职工酒精性肝病的流行病学调查  

An epidemiological survey of alcoholic liver disease among staff of Yanchang Oilfield

作　　者：李倩楠[1] 常剑波[1] 白艳霞[1] 万艳[1] 毕鑑红 戴光荣[1] LI Qiannan CHANG Jianbo BAI Yanxia et al(Department of Gastroenterology, Affiliated Hospital of Yan＇ an University, Yan＇an, Shannxi 716000, China)

机构地区：[1]延安大学附属医院消化科,陕西延安716000 [2]榆林市第一医院消化科,陕西榆林719000

出　　处：《临床肝胆病杂志》2017年第9期1769-1773,共5页Journal of Clinical Hepatology

基　　金：陕西省延安市科学技术研究发展计划项目(2015HM-13)

摘　　要：目的探讨延长油田职工酒精性肝病(ALD)的患病率及其危险因素。方法收集2016年6月延长油田职工健康体检者的资料,均接受人体学测量(身高、体质量、血压)、实验室检查(血常规、肝功能、血脂、血糖、病毒标志物)和上腹部超声检查,并填写完整的问卷调查。计数资料组间比较采用χ~2检验,多因素分析采用logistic回归分析法。结果共6723例健康体检者参与调查研究,检出ALD 397例,患病率5.91%。男性饮酒率(65.07%vs 15.75%)和ALD患病率(7.20%vs 1.11%)均高于女性(χ~2值分别为1107.48、75.34,P值均<0.001),男性是酒精消费的主要群体。不同文化程度的ALD患病率差异具有统计学意义(χ~2=86.598,P<0.001)。肥胖组的ALD患病率(17.70%)高于非肥胖组(9.27%),差异有统计学意义(χ~2=40.698,P<0.001)。随着日饮酒量的增加、饮酒时间的延长,ALD患病率逐渐增加,不同日饮酒量和饮酒年限的ALD患病率差异具有统计学意义(χ~2值分别为1147.428、116.542,P值均<0.001)。随着日饮酒量的增加,肝功能指标(GGT、ALT、AST)异常率会逐渐增加,差异具有统计学意义(χ~2值分别为250.013、199.027、151.459,P值均<0.001);随着饮酒年限的增长,肝功能指标(GGT、AST)异常率逐渐增加,其中GGT异常率差异具有统计学意义(χ~2=27.158,P<0.001)。肝功能、血压、血脂、肥胖、平均红细胞体积的异常率在饮酒组和对照组间差异均有统计学意义(χ~2值分别为51.272、9.988、316.430、80.675、13.570,P值均<0.05)。多因素分析显示,年龄、男性、肥胖、日饮酒量、饮酒方式、文化程度、GGT、AST、平均红细胞体积与ALD的发生密切相关(P值均<0.05)。结论延长油田职工ALD患病率较高,性别、年龄、文化程度、饮酒量、饮酒方式、肥胖是该地区成人ALD的主要影响因素。Objective To investigate the prevalence of alcoholic liver disease（ ALD） among the staff of Yanchang Oilfield and related risk factors. Methods The physical examination data were collected from the staff of Yanchang Oilfield in June 2016,and all the staff underwent anthropometric measurement（ body height,body weight,and blood pressure）,laboratory examinations（ routine blood test,liver function,blood lipids,blood glucose,and viral markers）,and upper abdominal ultrasound and completed the questionnaire. The chi-square test was used for comparison of categorical data between groups,and logistic regression was used for multivariate analysis. Results A total of 6723 employees participated in the study,among whom 397 had ALD,and the prevalence rate of ALD was 5. 91%. Compared with female staff,male staff had significantly higher drinking rate（ 65. 07% vs 15. 75%,χ~2= 1107. 48,P〈0. 001） and prevalence rate of ALD（ 7. 20% vs 1. 11%,χ~2= 75. 34,P〈0. 001）. Male population was the major group for alcohol consumption. There was a significant difference in the prevalence rate of ALD between the staff with different degrees of education（ χ~2= 86. 598,P〈0. 001）. The obese group had a significantly higher prevalence rate of ALD than the non-obese group（ 17. 70% vs 9. 27%,χ~2= 40. 698,P〈0. 001）. With the increases in drinking volume and drinking years,the prevalence rate of ALD gradually increased,and there was a significant difference in the prevalence rate of ALD between the staff with different daily drinking volumes and drinking years（ χ~2= 1147. 428 and 116. 542,both P〈0. 001）. With the increase in daily drinking volume,the abnormal rates of gamma-glutamyl transpeptidase（ GGT）,alanine aminotransferase,and aspartate aminotransferase（ AST） gradually increased（ χ~2= 250. 013,199. 027,and 151. 459,all P〈0. 001）; with the increase in drinking years,the abnormal rates of GGT and AST gradually increased,with a significant increase in the abnormal rate of GGT（ χ~2= 27.

关 键 词：肝疾病 酒精性 饮酒 患病率 危险因素 

分 类 号：R575[医药卫生—消化系统]