外泌体与肝脏疾病的关系  

Research advances in the association between exosomes and liver diseases

作　　者：吴俊成[1] 徐铭益[1] WU Juncheng XU Mingyi.(Department of Gastroenterology, Shanghai First People＇s Hospital, Shanghai Jiao Tong University, Shanghai 200080, Chin)

机构地区：[1]上海交通大学附属第一人民医院消化科,上海200080

出　　处：《临床肝胆病杂志》2017年第9期1815-1819,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81570547);国家科技部"十二五"重大专项(2012ZX10002007-001-040;2013ZX10002004-002-003);院优秀青年人才计划(061405)

摘　　要：外泌体是细胞经过"內吞-融合-外排"等过程形成的直径在30~100 nm的胞外囊泡。多种细胞均可以释放外泌体,这些外泌体可携带脂质、蛋白质和核酸等重要的生物分子,参与细胞间的信号转导及物质交换,调节体内多个系统的生理病理过程,其在多种肝脏疾病中发挥至关重要的作用,如肝癌、病毒性肝炎、肝纤维化、酒精性及非酒精性脂肪肝等。对外泌体在肝脏疾病中的研究进展作一综述。Exosomes are extracellular vesicles with a diameter of 30-100 nm formed during the processes of＂endocytosis-fusion-exocytosis＂. Exosomes can be released by various types of cells and may carry important biological molecules,such as lipids,proteins,and nucleic acids. They are also involved in signal transduction and exchange of substances between cells and can regulate the physiological and pathological processes in various systems. They also play an important role in liver diseases,including liver cancer,viral hepatitis,liver fibrosis,and alcoholic and non-alcoholic fatty liver disease. This article reviews the research advances in exosomes in liver diseases.

关 键 词：外泌体 肝疾病 综述 

分 类 号：R575[医药卫生—消化系统]