HPV检测联合TCT和SCC-Ag评估宫颈癌早期治疗效果的应用  

HPV testing joint TCT and SCC Ag assess cervical cancer early treatment effect

作　　者：潘静[1] 许艳茹[1] 闫泓霖[1] 姚丽艳[1] 

机构地区：[1]新疆医科大学第二附属医院妇产科,乌鲁木齐830028

出　　处：《检验医学与临床》2017年第18期2684-2685,共2页Laboratory Medicine and Clinic

基　　金：新疆医科大学科研创新基金(XJYDCX201534)

摘　　要：目的研究人乳头瘤病毒(HPV)检测联合液基细胞学(TCT)和鳞状细胞癌抗原(SCC-Ag)检查对宫颈癌早期治疗效果的评估价值。方法选取820例该院收治并疑诊早期宫颈癌患者,检测其HPV病毒水平并行TCT和血清SCC-Ag检测,以组织病理学确诊病情的分期,分析3项指标单项应用和联合应用对治疗后的评估效果,比较各自灵敏度、特异度、阳性预测值、阴性预测值及符合率。结果经组织病理学检查,820例患者中有262例阳性,558例阴性。单项检测的指标评价中,HPV检测的灵敏度最高(91.2%),SCC-Ag检测的特异度最高(90.1%)。联合3项指标评估后,灵敏度和特异度分别为97.3%和86.0%,与临床符合率高达90.2%,高于单项指标评估。结论 HPV检测联合TCT和SCC-Ag评估宫颈癌早期诊断的效果灵敏度和特异度均较好,符合率高,有较好的评估价值。Objective To Study human papilloma virus（HPV）joint liquid based cytology test（TCT）and squamous cell carcinoma antigen（SCC Ag）examination for early therapeutic effect evaluation value of cervical cancer.Methods 820 cases of patients suspected to early carcinoma of uterus cervical were collected and detected with the HPV virus,TCT and SCC Ag respectively.The definite diagnosis and the stage were confirmed by cervical biopsy.The diagnostic values of cervical cancer were analyzed among three individual indicators and joint application.The indexes of sensitivity,specificity,positive predictive value,negative predictive value and the coincidence rate were calculated and compared.Results The 262 cases were diagnosed to cervical cancer,and the 558 cases were negative by histopathological examination.The sensitivity of the HPV detection was highest（91.2%）among three individual indicators,and the specificity of the SCC-Ag detection was highest（90.1%）among three individual indicators.The sensitivity and specificity of joint indicator assessment were 97.3% and 86.0% respectively,and the clinical coincidence rate was 90.2%and higher than three individual indicators.Conclusion The joint indicator assessment to early stage of cervical cancer has perfect diagnostic value with better sensitivity,specificity and the coincidence rate.

关 键 词：宫颈癌 HPV TCT SCC-AG 评估 

分 类 号：R737.33[医药卫生—肿瘤]