高b值磁共振弥散加权成像在前列腺癌内分泌治疗中的应用价值  

Clinical application of high-b-value diffusion-weighted MR imaging in the treatment of endocrine of prostate cancer patients

作　　者：李香营[1] 韩向君 梁其洲[1] 陈晶[1] 程庆[3] LI Xiang-ying HAN Xiang-jun LIANG Qi-zhou CHEN Jing CHENG Qing(Department of Radiology, Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou 570208, Hainan, CHINA Department of Radiology, Kangya Hospital, Yiyang 413000, Hunan, CHINA Department of Urology, Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University/HaikouPeople＇s Hospital, Haikou 570208, Hainan, CHINA)

机构地区：[1]中南大学湘雅医学院附属海口医院/海口市人民医院放射科,海南海口570208 [2]湖南康雅医院放射科,湖南益阳413000 [3]中南大学湘雅医学院附属海口医院/海口市人民医院泌尿外科,海南海口570208

出　　处：《海南医学》2017年第16期2661-2662,共2页Hainan Medical Journal

基　　金：海南省卫生厅卫生科研自筹课题(编号:琼卫2013自筹-26)

摘　　要：目的探讨高b值3.0T磁共振弥散加权成像(DWI)在前列腺癌(PCa)患者内分泌治疗中的应用价值。方法收集海口市人民医院2014年1月至2016年9月40例经组织病理学确诊的PCa患者,分别在接受内分泌治疗前和治疗后1~2个月行DWI扫描,比较治疗前后前列腺癌区ADC值的差异。结果 40例PCa患者接受内分泌治疗前ADC值为(0.73±0.03)×10^(-3)mm^2/s,内分泌治疗1~2个月后ADC值为(1.10±0.08)×10^(-3)mm^2/s,较治疗前明显升高,差异有统计学意义(t=33.31,P=0.000)。结论 PCa患者接受内分泌治疗后ADC值升高,高b值DWI可间接反映PCa内分泌治疗后微观结构的变化,为临床评估PCa内分泌治疗效果提供了可能。Objective To investigate the clinical application of high-b-value diffusion-weighted（DW） magnetic resonance（MR） imaging（DWI） in the treatment of endocrine of prostate cancer patients. Methods Forty patients histologically confirmed prostate cancer（PCa） who underwent MRI scanning in our hospital from January 2014 to September 2016 were selected as the research objects. DWI with b value of 1 000 s/mm2 were performed before and 1 to 2months after endocrine therapy, and the apparent diffusion coefficient（ADC） values of prostate cancer tissue before and after the treatment were statistically analyzed. Results The ADC values of forty patients with PCa were（0.73±0.03）×10^-3mm^2/s before endocrine therapy, which was significantly lower than（1.10±0.08）×10^-3mm^2/s after 1-2 months of endocrine therapy（t=33.31, P=0.000）. Conclusion The ADC value increased after endocrine therapy for PCa patients,and high-b-value DWI can indirectly reflect the microstructure changes after PCa endocrine therapy, which can be used to evaluate the effect of PCa endocrine therapy.

关 键 词：前列腺癌 内分泌治疗 弥散加权成像 表观弥散系数 

分 类 号：R735.25[医药卫生—肿瘤]