绝经前后乳腺浸润性导管癌的蛋白表达及预后生存分析  

Analysis of Protein Expression and Prognosis Survival of Breast Infiltrating Ductal Carcinoma before and after Menopause

作　　者：刘文娟 刘文慧[2] 张海涛 张秋瑾[2] 

机构地区：[1]成武县人民医院病理科,山东菏泽2742001 [2]桂林医学院免疫学教研室,广西桂林541004

出　　处：《系统医学》2017年第9期8-11,共4页Systems Medicine

基　　金：2015年度广西壮族自治区高等学校科学研究(02010150018)

摘　　要：目的探讨绝经前后ER、PR、HER-2表达及其与临床病理特征相关性,并分析其预后生存情况。方法采用免疫组化法检测山东省菏泽市成武县人民医院2011年1月—2015年1月期间收治的156例乳腺浸润性导管癌患者肿瘤组织ER、PR、HER-2的表达,并根据患者绝经与否分为绝经组与未绝经组。统计学分析未绝经组(60例)与绝经组(96例)患者ER、PR、HER-2表达的差异及其对肿瘤大小、TNM分期等临床病理参数的影响,并对其中66例患者进行随访,分析其预后生存情况。结果绝经组患者共96例,其ER、PR、HER-2阳性率分别为76.0%,59.4%,17.7%,未绝经组患者共60例,其ER、PR、HER-2阳性率分别是40.0%,28.3%,63.3%,两组患者三者的表达均差异有统计学意义(P<0.05)。患者是否绝经与乳腺浸润性导管癌中ER、PR、HER-2阳性表达及三阴性乳腺癌呈现明显线性相关(P<0.05),而与肿瘤直径、TNM分期未呈现明显线性相关性(P>0.05)。生存分析中,绝经组存活率(67.57%)高于未绝经组(37.93%),死亡率(18.92%)低于未绝经组(48.28%),预后生存期较未绝经组长。结论乳腺浸润性导管癌患者蛋白的差异性表达和预后生存状况与是否绝经关系密切,是否绝经对乳腺浸润性导管癌治疗方案的选择及预后判定有重要参考意义。Objective To s tud y th e co rrelation b etwe en th e ER , PR, HE R- 2 ex p res sion an d c l in ic a l path o lo gical fe a -tures before and af ter menopause and analyze the prognosis survival s ituat ion. Methods T he ER , PR, H E R - 2 e x p re s -sions of tumor tissues of pat ients with breas t infi ltrating ductal carcinoma from January 2011 to January 2015 was test -ed by the immunohistochemistry, and divided into the menopause group and non-menopause group, and the effect of differences in the ER、 P R、 H E R -2 of p a t ien ts in th e n o n -m e n o p a u se group with 6 0 c a se s an d m en o pause group with 96 cases on the tumor size and TNM stage was s tat is t ical ly analyzed, and 66 cases of pat ients were followed up, and the survival prognosis s ituat ion was analyzed. Results In th e m en o pause group, th e positive ra te s of E R、 P R、 H E R - 2 was respect ively 76.0% , 5 9 .4% , 17.7%, and in th e n o n -m e n o p a u s e group, th e positive ra te of E R、 P R、 H E R - 2 was re sp ectively 40.0% 袁 36 .7% 袁 6 3 .3%, an d th e differenc e in th e ex p res sion b etwe en th e two groups was s ta t is t ic a lly significant （P〈0.05） , and whether the pat ients were with menopause or not had an obvious l iner correlation with the positive ex-pres sion of ER, PR, HER-2 and TNBC（P〈0.05）, and had an obvious l iner correlation with the tumor diameter and TNM stage （P〉0.05）, and the survival analys is showed that the survival rate in the menopause group was higher than that in the non-menopause group （67.57% vs 37.93%） , and the morbidi ty was lower than that in the non-menopause group, （18.92% vs 48.28%） , and the prognosis survival stage was longer than that in the non-menopause group. Conclusion The difference expres sion of protein of pat ients with breas t infi ltrating ductal carcinoma is closely correlated with the prognosis survival s ituat ion, and menopause is of im

关 键 词：绝经 浸润性导管癌 雌激素受体 孕激素受体 人表皮生长因子受体-2 

分 类 号：R737.9[医药卫生—肿瘤]