胃肠恶性间质细胞瘤的手术和靶向治疗的分析  

Analysis of Surgery of Gastrointestinal Malignant Interstitial Tumor and Targeted Therapy

作　　者：李斌 江媛 

机构地区：[1]山东能源淄矿集团中心医院普通外科,山东淄博255120 [2]山东能源淄矿集团中心医院高压氧科,山东淄博255120

出　　处：《系统医学》2017年第12期102-104,共3页Systems Medicine

摘　　要：目的分析胃肠恶性间质细胞瘤的手术以及靶向治疗方法与临床效果。方法该研究病例观察时间段为2014年1月—2015年1月,收集该院住院部收治胃肠恶性间质细胞瘤患者共60例作为研究对象,用随机抽签方法分组,对照组(n=30),观察组(n=30)。对照组患者单纯实施手术治疗,观察组患者术后联合实施靶向治疗。对两组患者进行为期2年随访观察,对术后复发、远端转移率以及死亡率进行对比分析。结果对比两组随访2年期间临床结果,观察组术后复发率为6.67%(2/30),远端转移率为3.33%(1/30),死亡率为3.33%(1/30),均显著高于对照组,差异有统计学意义(P<0.05)。结论在对胃肠恶性间质细胞瘤患者进行手术治疗的基础之上,联合采用靶向治疗手段进行辅助治疗,能够有效预防病灶复发与远端转移,延长患者生存时间,值得在临床实践中推广应用。Objective This paper tries to analyze clinical effect of the surgery of gastrointestinal malignant interstitial tumor and targeted therapy. Methods A total of 60 patients with gastrointestinal malignant interstitial tumor admitted in this hospital from January 2014 to January 2015 were selected and divided into two groups by random sampling method, with 30 cases in each group. The patients in the control group were treated with surgery, and the patients in the observation group were treated with targeted therapy. Two groups of patients were followed up for 2 years, and the postoperative recurrence, distal metastasis rate and mortality were compared and analyzed. Results The postoperative recurrence, distal metastasis and mortality rate in the observation group were 6.67%（2/30）, 3.33%（1/30） and 3.33%（1/30）, significantly higher than the control group, the difference was statistically significant（P0.05）. Conclusion Targeted therapy combined with surgical treatment of patients with gastrointestinal malignant intertitial tumor can effectively prevent recurrence and distal metastasis and prolong the survival time of patients. It is worth clinical application.

关 键 词：胃肠 恶性间质细胞瘤 手术 靶向治疗 

分 类 号：R735[医药卫生—肿瘤]